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Journal of Obesity
Volume 2011 (2011), Article ID 435245, 9 pages
http://dx.doi.org/10.1155/2011/435245
Review Article

Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function

1Institute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway
2Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway

Received 2 September 2010; Accepted 14 December 2010

Academic Editor: Francesco Saverio Papadia

Copyright © 2011 Simon N. Dankel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term randomized controlled trials should be performed that include simultaneous measurement of metabolic parameters in different tissues, such as tissue gene expression, protein profile, and lipid content. By directly comparing different surgical procedures using a wider array of metabolic parameters, one may further unravel the mechanisms of aberrant metabolic regulation in obesity and related disorders.