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Journal of Obesity
Volume 2011, Article ID 495101, 7 pages
http://dx.doi.org/10.1155/2011/495101
Research Article

Vitamin D Deficiency in Obese Children and Its Relationship to Insulin Resistance and Adipokines

1Division of Endocrinology, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
2Department of Pediatrics Bonn, University of Bonn, Germany
3Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
4Department of Medicine, University of Washington, Seattle, WA 98195, USA
5Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
6Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA

Received 10 August 2011; Accepted 17 September 2011

Academic Editor: P. Trayhurn

Copyright © 2011 Christian L. Roth et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. R. Kaufman and J. Shaw, “Type 2 diabetes in youth: rates, antecedents, treatment, problems and prevention,” Pediatric Diabetes, vol. 8, no. 9, pp. 4–6, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Rajakumar, J. D. Fernstrom, M. F. Holick, J. E. Janosky, and S. L. Greenspan, “Vitamin D status and response to vitamin D3 in obese vs. non-obese African American children,” Obesity, vol. 16, no. 1, pp. 90–95, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. L. Bradlee, M. R. Singer, M. M. Qureshi, and L. L. Moore, “Food group intake and central obesity among children and adolescents in the Third National Health and Nutrition Examination Survey (NHANES III),” Public Health Nutrition, vol. 13, no. 6, pp. 797–805, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Muscogiuri, G. P. Sorice, A. Prioletta et al., “25-hydroxyvitamin D concentration correlates with insulin-sensitivity and BMI in obesity,” Obesity, vol. 18, no. 10, pp. 1906–1910, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Targher, L. Bertolini, L. Scala et al., “Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 7, pp. 517–524, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. M. Lenders, H. A. Feldman, E. Von Scheven et al., “Relation of body fat indexes to vitamin D status and deficiency among obese adolescents,” American Journal of Clinical Nutrition, vol. 90, no. 3, pp. 459–467, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. S. Dusso, A. J. Brown, and E. Slatopolsky, “Vitamin D,” American Journal of Physiology, vol. 289, no. 1, pp. F8–F28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. I. H. de Boer, B. Kestenbaum, A. B. Shoben, E. D. Michos, M. J. Sarnak, and D. S. Siscovick, “25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification,” Journal of the American Society of Nephrology, vol. 20, no. 8, pp. 1805–1812, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Kendrick, G. Targher, G. Smits, and M. Chonchol, “25-hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey,” Atherosclerosis, vol. 205, no. 1, pp. 255–260, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Kadowaki and A. W. Norman, “Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas,” Journal of Clinical Investigation, vol. 73, no. 3, pp. 759–766, 1984. View at Google Scholar · View at Scopus
  11. B. Billaudel, L. Barakat, and A. Faure-Dussert, “Vitamin D3 deficiency and alterations of glucose metabolism in rat endocrine pancreas,” Diabetes and Metabolism, vol. 24, no. 4, pp. 344–350, 1998. View at Google Scholar · View at Scopus
  12. U. Zeitz, K. Weber, D. W. Soegiarto, E. Wolf, R. Balling, and R. G. Erben, “Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor,” The FASEB Journal, vol. 17, no. 3, pp. 509–511, 2003. View at Google Scholar · View at Scopus
  13. A. Ashraf and J. A. Alvarez, “Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis,” International Journal of Endocrinology, vol. 2010, Article ID 351385, 18 pages, 2010. View at Publisher · View at Google Scholar
  14. A. G. Need, P. D. O'Loughlin, M. Horowitz, and B. E. C. Nordin, “Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women,” Clinical Endocrinology, vol. 62, no. 6, pp. 738–741, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Scragg, M. Sowers, and C. Bell, “Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey,” Diabetes Care, vol. 27, no. 12, pp. 2813–2818, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Hyppönen, B. J. Boucher, D. J. Berry, and C. Power, “25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 british birth cohort,” Diabetes, vol. 57, no. 2, pp. 298–305, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. K. C. Chiu, A. Chu, V. L. W. Go, and M. F. Saad, “Hypovitaminosis D is associated with insulin resistance and β cell dysfunction,” American Journal of Clinical Nutrition, vol. 79, no. 5, pp. 820–825, 2004. View at Google Scholar · View at Scopus
  18. B. Thorand, A. Zierer, C. Huth et al., “Effect of serum 25-hydroxyvitamin D on risk for type 2 diabetes may be partially mediated by subclinical inflammation: results from the monica/kora augsburg study,” Diabetes Care, vol. 34, no. 10, pp. 2320–2322, 2011. View at Publisher · View at Google Scholar
  19. O. Gedik and S. Akalin, “Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man,” Diabetologia, vol. 29, no. 3, pp. 142–145, 1986. View at Google Scholar · View at Scopus
  20. C. L. Roth, M. Kratz, M. M. Ralston, and T. Reinehr, “Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children,” Metabolism, vol. 60, pp. 445–452, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. N. Hoofnagle, “Quantitative clinical proteomics by liquid chromatography—tandem mass spectrometry: assessing the platform,” Clinical Chemistry, vol. 56, no. 2, pp. 161–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Reinehr and C. L. Roth, “A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss,” International Journal of Obesity, vol. 34, no. 5, pp. 852–858, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. W. A. Marshall and J. M. Tanner, “Variations in pattern of pubertal changes in girls,” Archives of Disease in Childhood, vol. 44, no. 235, pp. 291–303, 1969. View at Google Scholar · View at Scopus
  24. W. A. Marshall and J. M. Tanner, “Variations in the pattern of pubertal changes in boys,” Archives of Disease in Childhood, vol. 45, no. 239, pp. 13–23, 1970. View at Google Scholar · View at Scopus
  25. L. S. Conwell, S. G. Trost, W. J. Brown, and J. A. Batch, “Indexes of insulin resistance and secretion in obese children and adolescents: a validation study,” Diabetes Care, vol. 27, no. 2, pp. 314–319, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. A. K. Saenger, T. J. Laha, D. E. Bremner, and S. M. H. Sadrzadeh, “Quantification of serum 25-hydroxyvitamin D2 and D3 using HPLC-tandem mass spectrometry and examination of reference intervals for diagnosis of vitamin D deficiency,” American Journal of Clinical Pathology, vol. 125, no. 6, pp. 914–920, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. A. N. Hoofnagle, T. J. Laha, and T. F. Donaldson, “A rubber transfer gasket to improve the throughput of liquid-liquid extraction in 96-well plates: application to vitamin D testing,” Journal of Chromatography B, vol. 878, no. 19, pp. 1639–1642, 2010. View at Publisher · View at Google Scholar
  28. J. Kumar, P. Muntner, F. J. Kaskel, S. M. Hailpern, and M. L. Melamed, “Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004,” Pediatrics, vol. 124, no. 3, pp. e362–e370, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. E. E. Delvin, M. Lambert, E. Levy et al., “Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents,” Journal of Nutrition, vol. 140, no. 5, pp. 987–991, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Lagunova, A. C. Porojnicu, F. A. Lindberg, L. Aksnes, and J. Moan, “Vitamin D status in Norwegian children and adolescents with excess body weight,” Pediatric Diabetes, vol. 12, no. 2, pp. 120–126, 2011. View at Publisher · View at Google Scholar
  31. M. F. Holick, “Medical progress: vitamin D deficiency,” The New England Journal of Medicine, vol. 357, no. 3, pp. 266–281, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Rajakumar, J. de Las Heras, T. C. Chen, S. Lee, M. F. Holick, and S. A. Arslanian, “Vitamin D status, adiposity, and lipids in black American and Caucasian children,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 5, pp. 1560–1567, 2011. View at Publisher · View at Google Scholar
  33. B. Hintzpeter, C. Scheidt-Nave, M. J. Müller, L. Schenk, and G. B. M. Mensink, “Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany,” Journal of Nutrition, vol. 138, no. 8, pp. 1482–1490, 2008. View at Google Scholar · View at Scopus
  34. A. Giulietti, E. van Etten, L. Overbergh, K. Stoffels, R. Bouillon, and C. Mathieu, “Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-dihydroxyvitamin D3 works as anti-inflammatory,” Diabetes Research and Clinical Practice, vol. 77, no. 1, pp. 47–57, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Kayaniyil, R. Vieth, S. B. Harris et al., “Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 1, pp. 168–175, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Hyppönen, E. Läärä, A. Reunanen, M.-R. Järvelin, and S. M. Virtanen, “Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study,” The Lancet, vol. 358, no. 9292, pp. 1500–1503, 2001. View at Publisher · View at Google Scholar
  37. X. Palomer, J. M. González-Clemente, F. Blanco-Vaca, and D. Mauricio, “Role of vitamin D in the pathogenesis of type 2 diabetes mellitus,” Diabetes, Obesity and Metabolism, vol. 10, no. 3, pp. 185–197, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. M. D. Witham, F. J. Dove, M. Dryburgh, J. A. Sugden, A. D. Morris, and A. D. Struthers, “The effect of different doses of vitamin D3 on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial,” Diabetologia, vol. 53, no. 10, pp. 2112–2119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Kayaniyil, R. Vieth, R. Retnakaran et al., “Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes,” Diabetes Care, vol. 33, no. 6, pp. 1379–1381, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. T. Zarrabeitia, J. A. Riancho, J. A. Amado, J. M. Olmos, and J. Gonzalez-Macias, “Effect of calcitriol on the secretion of prostaglandin E2, interleukin 1, and tumor necrosis factor α by human monocytes,” Bone, vol. 13, no. 2, pp. 185–189, 1992. View at Publisher · View at Google Scholar · View at Scopus
  41. Z. Li, S. Yang, H. Lin et al., “Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease,” Hepatology, vol. 37, no. 2, pp. 343–350, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Kanda, S. Tateya, Y. Tamori et al., “MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity,” Journal of Clinical Investigation, vol. 116, no. 6, pp. 1494–1505, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. C. L. Roth, C. T. Elfers, D. P. Figlewicz et al., “Vitamin D deficiency in obese rats exacerbates NAFLD and increases hepatic resistin and toll-like receptor activation,” Hepatology. In press. View at Publisher · View at Google Scholar
  44. R. Alemzadeh, J. Kichler, G. Babar, and M. Calhoun, “Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season,” Metabolism, vol. 57, no. 2, pp. 183–191, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Nunlee-Bland, K. Gambhir, C. Abrams, M. Abdul, M. Vahedi, and W. Odonkor, “Vitamin D deficiency and insulin resistance in obese African-American adolescents,” Journal of Pediatric Endocrinology and Metabolism, vol. 24, no. 1-2, pp. 29–33, 2011. View at Publisher · View at Google Scholar
  46. J. C. Winer, T. L. Zern, S. E. Taksali et al., “Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 11, pp. 4415–4423, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Reinehr, C. Roth, T. Menke, and W. Andler, “Adiponectin before and after weight loss in obese children,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 8, pp. 3790–3794, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. A. Vidal-Puig and S. O'Rahilly, “Resistin: a new link between obesity and insulin resistance?” Clinical Endocrinology, vol. 55, no. 4, pp. 437–438, 2001. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Qatanani, N. R. Szwergold, D. R. Greaves, R. S. Ahima, and M. A. Lazar, “Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice,” Journal of Clinical Investigation, vol. 119, no. 3, pp. 531–539, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. E. Szalowska, M. G. L. Elferink, A. Hoek, G. M. M. Groothuis, and R. J. Vonk, “Resistin is more abundant in liver than adipose tissue and is not up-regulated by lipopolysaccharide,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 8, pp. 3051–3057, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. C. M. Kusminski, P. G. McTernan, and S. Kumar, “Role of resistin in obesity, insulin resistance and type II diabetes,” Clinical Science, vol. 109, no. 3, pp. 243–256, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. C. L. Roth and T. Reinehr, “Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention,” Archives of Pediatrics and Adolescent Medicine, vol. 164, no. 2, pp. 131–138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  53. T. Reinehr, G. de Sousa, U. Alexy, M. Kersting, and W. Andler, “Vitamin D status and parathyroid hormone in obese children before and after weight loss,” European Journal of Endocrinology, vol. 157, no. 2, pp. 225–232, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Tzotzas, F. G. Papadopoulou, K. Tziomalos et al., “Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 9, pp. 4251–4257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  55. Y. Dong, I. S. Stallmann-Jorgensen, N. K. Pollock et al., “A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 10, pp. 4584–4591, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. A. C. Ross, J. E. Manson, S. A. Abrams et al., “The 2011 dietary reference intakes for calcium and vitamin D: what dietetics practitioners need to know,” Journal of the American Dietetic Association, vol. 111, no. 4, pp. 524–527, 2011. View at Publisher · View at Google Scholar
  57. M. Misra, D. Pacaud, A. Petryk, P. F. Collett-Solberg, and M. Kappy, “Vitamin D deficiency in children and its management: review of current knowledge and recommendations,” Pediatrics, vol. 122, no. 2, pp. 398–417, 2008. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Ding, I. Schoenmakers, K. Jones, A. Koulman, A. Prentice, and D. A. Volmer, “Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS/MS,” Analytical and Bioanalytical Chemistry, vol. 398, no. 2, pp. 779–789, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. E. A. Yetley, C. M. Pfeiffer, R. L. Schleicher et al., “NHANES monitoring of serum 25-hydroxyvitamin D: a roundtable summary,” Journal of Nutrition, vol. 140, no. 11, pp. 2030S–2045S, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. J. H. Himes, “Challenges of accurately measuring and using BMI and other indicators of obesity in children,” Pediatrics, vol. 124, no. 1, pp. S3–S22, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. D. S. Freedman, J. Wang, J. C. Thornton et al., “Racial/ethnic differences in body fatness among children and adolescents,” Obesity, vol. 16, no. 5, pp. 1105–1111, 2008. View at Publisher · View at Google Scholar · View at Scopus