Relationships of Adrenoceptor Polymorphisms with Obesity

Table 2

Summary of studies showing associations between β2-adrenoceptor polymorphisms and obesity.

Authors [reference]	Year	Population	Subjects	Findings
Large et al. [55]	1997	Swedish	Caucasian women with wide range of obesity	Gln27Glu polymorphism was associated with obesity.
Echwald et al. [58]	1998	Danes	Caucasian juvenile-onset obese men	No association between Gln27Glu and obesity.
Hellström et al. [59]	1999	Swedish	Swedish-Caucasian men and women	Gln27Glu polymorphism was associated with obesity only in women, but not in men.
Kortner et al. [69]	1999	German	Caucasian with morbid obesity	Gln27Glu polymorphism was not associated with obesity.
The Quebec Family Study [70]	2000	Canadian	Caucasian men and women	Gln27Glu polymorphism was associated with obesity and hyperlipidemia.
Ukkola et al. [56]	2001	USA	12 pairs of twins, Caucasians	Gln27Glu polymorphism was associated with weight gain (obesity).
Meirhaeghe et al. [71]	2000	French	1,195 subjects	Subjects carrying Gln27 homozygous had an increased risk of obesity in men, but not in women. Further, men with Gln27 homozygous carried in addition the Arg16 allele, had more significant increase in body weight, BMI and waist-to-hip ratio (central obesity).
The HERITAGE family study [72]	2003	Canada	Sedentary black and white men	Gln27Glu polymorphism was associated with lower fat in obese white men.
Pereira et al. [25]	2003	Brazilian	1,576 individuals randomly selected	Subjects carrying Gln27 homozygous had higher risk of obesity, whereas those with Gly27 homozygous had increased risk of hypertension.
Jiao et al. [73]	2005	Scandinavian	1,354 women and 421 men	Common haplotypes of ADRB2 polymorphisms had recessive effects against excess body fat only in women, but not in men.
Masuo et al. [26]	2005	Japanese	154 overweight/obese men	Gly16 allele was related to obesity and rebound weight gain in weight-loss study.
Masuo et al. [24, 27]	2005	Japanese	160 nonobese, normotensive men	Gly16 allele was related to future weight gain, BP elevation and insulin resistance in originally nonobese, normotensive men.
Masuo et al. [28]	2006	Japanese	329 normotensive men with a wide range of BMI	Gly16 and Glu27 alleles were related to obesity through blunted-leptin-mediated sympathetic activity.
Kawaguchi et al. [29]	2006	Japanese	55 overweight/obese men	Gly16 allele was related to further weight gain in obese subjects.
Petrone et al. [74]	2006	European	642 overweight/obese subjects	The haplotype of 5′LC-Cys(19)Arg(16)Gln(27) was related to additional weight gain with increases of triglycerides and LDL-cholesterol.
Gjesing et al. [75]	2009	Danes	6,514 adults	No consistent effect of ADRB2 haplotypes on obesity and quantitative traits of body fatness.

ADRB2: β2-adrenoceptors; BP: blood pressure.