Figure 1: Effect of a high-fat diet and treatment with AVE7688 on glucose tolerance. Rats were fed a standard or high-fat diet with or without AVE7688, Enalapril, or Candoxatril for 24 weeks. Afterwards glucose tolerance was determined as described in Section. Data are presented as the mean ± SEM in mg/dL. The area under the curve (AUC) was significantly different for high-fat fed rats versus control. There was no significant difference for AUC between rats fed a high-fat diet containing AVE7688 and control or high-fat fed rats. Feeding rats a high-fat diet containing Enalapril or Candoxatril provided no improvement in impaired glucose tolerance caused by the high-fat diet. The number of rats in each group was the same as shown in Table 1.