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Journal of Obesity
Volume 2011, Article ID 959601, 8 pages
Research Article

Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet

1Department of Radiology, Uppsala University, 751 85 Uppsala, Sweden
2Department of Surgery, Uppsala University, 751 85 Uppsala, Sweden
3Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden
4Philips Research Europe, D-22335 Hamburg, Germany
5Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden

Received 2 August 2010; Revised 1 October 2010; Accepted 13 October 2010

Academic Editor: Francesco Saverio Papadia

Copyright © 2011 Joel Kullberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Recently, we found large reductions in visceral and subcutaneous fat one month after gastric bypass (GBP), without any change in liver fat content. Purpose. Firstly to characterize weight loss-induced lipid mobilization after one month with preoperative low-calorie diet (LCD) and a subsequent month following GBP, and secondly, to discuss the observations with reference to our previous published findings after GBP intervention alone. Methods. 15 morbidly obese women were studied prior to LCD, at GBP, and one month after GBP. Effects on metabolism were measured by magnetic resonance techniques and blood tests. Results. Body weight was similarly reduced after both months (mean: −8.0 kg, ). Relative body fat changes were smaller after LCD than after GBP ( % versus %, , ). Liver fat fell during the LCD month (−41%, , ) but was unaltered one month after GBP (+12%). Conclusion. Gastric bypass seems to cause a greater lipid mobilization than a comparable LCD-induced weight loss. One may speculate that GBP-altered gastrointestinal signalling sensitizes adipose tissue to lipolysis, promoting the changes observed.