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Journal of Obesity
Volume 2012, Article ID 857510, 8 pages
Clinical Study

Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

1Department of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USA
2Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
3Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA
4School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
5Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA

Received 26 January 2012; Revised 18 April 2012; Accepted 26 April 2012

Academic Editor: Jenifer I. Fenton

Copyright © 2012 Lyla Blake-Gumbs et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2 change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.