Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

Table 3

Odds ratios (ORs) of colon cancer for changes in BMI over time by age, decades^a.

		All postmenopausal women				Postmenopausal women with no HRT				Postmenopausal women with HRT
	kg/m^2	Case/control	OR	𝑃	𝑃^∗	Case/control	OR	𝑃	𝑃^∗	Case/control	OR	𝑃	𝑃^∗
Change in BMI in 50s	<5 (ref)^c	366/691	1.00	—	—	189/259	1.00	—	—	177/432	1.00	—	—
	5–10	57/91	0.92 (0.61–1.40)	0.71	—	42/42	1.15 (0.66–1.99)	0.62	—	15/49	0.67 (0.17–2.65)	0.42	—
	>10	12/23	0.62 (0.27–1.43)	0.26	0.47	9/11	0.72 (0.24–2.16)	0.56	0.90	3/12	1.02 (0.66–1.58)	0.57	0.47
Change in BMI in 40s	<5 (ref)	286/587	1.00	—	—	142/208	1.00	—	—	144/379	1.00	—	—
	5–10	105/192	0.90 (0.64–1.26)	0.55	—	63/85	0.86 (0.53–1.40)	0.54	—	42/107	0.93 (0.56–1.52)	0.76	—
	>10	35/51	0.98 (0.57–1.69)	0.95	0.88	23/28	0.82 (0.39–1.70)	0.59	0.59	12/23	1.24 (0.54–2.86)	0.62	0.65
Change in BMI in 30s	<5 (ref)	197/473	1.00	—	—	94/171	1.00	—	—	103/302	1.00	—	—
	5–10	158/256	1.48 (1.06–2.07)	0.02	—	94/98	1.91 (1.16–3.17)	0.01	—	64/158	1.22 (0.76–1.95)	0.41	—
	>10	72/109	1.51 (0.94–2.43)	0.09	0.02	44/50	1.79 (0.90–3.55)	0.10	0.0498	28/59	1.57 (0.79–3.12)	0.20	0.10
Change in BMI in 20s	<5 (ref)	152/368	1.00	—	—	77/138	1.00	—	—	75/230	1.00	—	—
	5–10	182/313	1.54 (1.09–2.19)	0.02	—	91/110	1.77 (1.02–3.05)	0.04	—	91/203	1.41 (0.88–2.27)	0.16	—
	>10	122/185	1.45 (0.90–2.33)	0.12	0.049	83/81	2.21 (1.09–4.45)	0.03	0.02	39/104	1.11 (0.56–2.19)	0.76	0.38

^aAdjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, family history of colorectal cancer, age at menarche, and parity. Analysis additionally adjusted for baseline BMI (BMI in the “recruitment period,” 2 years before recruitment). ^c<5 kg/m² (weight gain of approximately <25 lbs); 5–10 kg/m² (weight gain of ~25–50 lbs) and >10 kg/m² (weight gain exceeding 50 lbs). ^*𝑃 value for trend.