Table 3: Odds ratios (ORs) of colon cancer for changes in BMI over time by age, decadesa.

All postmenopausal womenPostmenopausal women with no HRTPostmenopausal women with HRT
kg/m2Case/controlOR 𝑃 𝑃 Case/controlOR 𝑃 𝑃 Case/controlOR 𝑃 𝑃

Change in BMI in 50s<5 (ref)c366/6911.00189/2591.00177/4321.00
5–1057/910.92 (0.61–1.40)0.7142/421.15 (0.66–1.99)0.6215/490.67 (0.17–2.65)0.42
>1012/230.62 (0.27–1.43)0.260.479/110.72 (0.24–2.16)0.560.903/121.02 (0.66–1.58)0.570.47
Change in BMI in 40s<5 (ref)286/5871.00142/2081.00144/3791.00
5–10105/1920.90 (0.64–1.26)0.5563/850.86 (0.53–1.40)0.5442/1070.93 (0.56–1.52)0.76
>1035/510.98 (0.57–1.69)0.950.8823/280.82 (0.39–1.70)0.590.5912/231.24 (0.54–2.86)0.620.65
Change in BMI in 30s<5 (ref)197/4731.0094/1711.00103/3021.00
5–10158/2561.48 (1.06–2.07)0.0294/981.91 (1.16–3.17)0.0164/1581.22 (0.76–1.95)0.41
>1072/1091.51 (0.94–2.43)0.090.0244/501.79 (0.90–3.55)0.100.049828/591.57 (0.79–3.12)0.200.10
Change in BMI in 20s<5 (ref)152/3681.0077/1381.0075/2301.00
5–10182/3131.54 (1.09–2.19)0.0291/1101.77 (1.02–3.05)0.0491/2031.41 (0.88–2.27)0.16
>10122/1851.45 (0.90–2.33)0.120.04983/812.21 (1.09–4.45)0.030.0239/1041.11 (0.56–2.19)0.760.38

aAdjusted for age, race, gender, education, income, physical activity, smoking, alcohol, nonsteroidal anti-inflammatory drugs use, family history of colorectal cancer, age at menarche, and parity. Analysis additionally adjusted for baseline BMI (BMI in the “recruitment period,” 2 years before recruitment). c<5 kg/m2 (weight gain of approximately <25 lbs); 5–10 kg/m2 (weight gain of ~25–50 lbs) and >10 kg/m2 (weight gain exceeding 50 lbs). * 𝑃 value for trend.