Journal of Obesity

Review Article

Genetics of Obesity and Type 2 Diabetes in African Americans

Table 2

(a) MC4R variation and BMI in populations of African ancestry. (b) Degree of linkage disequilibrium between MC4R SNPs in Table 2(a) in the YRI population [12].

(a)


MC4R SNP	Population (n, study, reference)	Minor allele	Minor allele frequency	P value for association with BMI

rs17782313	Meta-analysis, 6 AA cohorts (n = 4,992) [21]	C	0.29	0.082
	South African adults (birth to age 20) (n = 990) [17]	C	0.25	0.045
	African decent, adults (PAGE) [50]	C	0.29	0.04
	Meta-analysis, 6 AA cohorts (n = 4,992) [21]			0.02 (Effect opposite risk allele)
rs571312	AA children CHOP (n = 3,723) [51]	T	0.335	0.348
rs10871777	AA children CHOP (n = 3,723) [51]	G	0.286	0.161
rs476828	AA children CHOP (n = 3,723) [51]	G	0.412	0.825
rs1942880	AA children CHOP (n = 3,723) [51]	C	0.499	0.008
rs12457166	AA children CHOP (n = 3,723) [51]	A	0.230	0.013
rs633265	Meta-analysis 6 AA cohorts (n = 4,992) [21]	C	0.22	0.455
rs633265	AA children CHOP (n = 3,723) [51]	C	0.248	0.075
rs477181	Meta-analysis 6 AA cohorts (n = 4992) [21]	G	0.47	0.018
rs477181	AA children CHOP (n = 3,723) [51]	G	0.492	0.252
rs4450508	Meta-analysis, 6 AA cohorts (n = 4,992) [21]	A	0.30	0.046
rs6567160	AA (n = 743), Nigerian (n = 1,188) [52]	C (reference allele)		0.0035
	AA adults (GCI) (n = 494) [52]	C (reference allele)		0.227
	AA adults (Maywood) (n = 756) [52]	C (reference allele)		0.024
	African-derived adults (Jamaica G × E) (n = 959) [52]	C (reference allele)		0.497
	African-derived adults (Jamaica SPT) (n = 1,478) [52]	C (reference allele)		0.021

(b)


(YRI)	rs17782313	rs571312	rs10871777	rs476828	rs1942880	rs12457166	rs633265	rs477181	rs4450508	rs6561760

rs17782313	1
rs571312	0.258	1
rs10871777	0.924	0.204	1
rs476828	0.503	0.472	0.544	1
rs1942880	0.206	0.121	0.227	0.241	1
rs12457166	0.000	0.001	0.001	0.004	0.074	1
rs633265	0.064	0.083	0.069	0.127	0.150	0.041	1
rs477181	0.140	0.118	0.166	0.329	0.013	0.255	0.161	1
rs4450508	0.131	0.002	0.184	0.340	0.008	0.103	0.067	0.413	1
rs6561760	0.086	0.012	0.068	0.000	0.172	0.068	0.035	0.007	0.042	1