Figure 1: Dose response of acute nisoxetine or saline on the re-feeding intake of standard chow. Animals underwent a 24 h food deprivation prior to injections and refeeding. All animals were fed and maintained on standard chow (13% fat, 27% protein). Doses were randomly administered with a week washout between doses. (a) Intake (Kcal) shown is cumulative. # indicates differences ( ) from all other doses. (b) Data expressed as ratio of food intake following saline at the individual time points. Dotted line represents intake from saline injected animals (ratio of 1.0) to illustrate the feeding suppression of nisoxetine. Asterisks indicate significant differences ( ) from 3 mg/kg dose at respective time point.