High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor
Dose response of hemodynamic measurements of acute nisoxetine or saline. Animals underwent a 24 h food deprivation prior to injections and refeeding. All animals were fed and maintained on standard chow (13% fat, 27% protein). Doses were randomly administered with a week washout between doses and tail-cuff volume pressure recording were performed at 1 h, 4 h, and 24 h. (a). Mean blood pressure (b). Systolic blood pressure (c). Diastolic blood pressure (d). Heart rate. Asterisks indicate difference from saline () at the individual time points.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.