Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 1

Body weight as area under the curve (AUC). Body weight was recorded weekly from weaning at week 3 until termination at week 11 and is presented for Apc^Min/+ (a) females and (b) males, and Apc^+/+ (c) females and (d) males (mean ± SD). The mice were exposed to 0.9% NaCl and given a 10% fat diet (white columns) or 0.9% NaCl and a 45% fat diet (light grey columns), or they were exposed to PhIP and given a 10% fat diet (dark grey columns) or PhIP and a 45% fat diet (black columns). –18 mice. a.u. = arbitrary units.

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