Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 3

The size of the small intestinal tumors. This is illustrated by curves of distributions of tumors size classes (of 0.25 mm tumor diameter intervals) calculated as mean number of tumors in each tumor size class for each treatment group. The effect of a 45% fat diet compared with a 10% fat diet is shown for female Apc^Min/+ X Lep^ob/ob mice (○), Apc^Min/+ X Lep^ob/wt (∆) and Apc^Min/+ X Lep^wt/wt mice (□) on a 10% fat diet, and the same genotypes on a 45% fat diet (filled symbols) exposed to (a) 0.9% NaCl, or (b) PhIP. The effect of exposure to PhIP compared with 0.9% NaCl is shown for male Apc^Min/+ X Lep^ob/ob mice (○), Apc^Min/+ X Lep^ob/wt (∆) and Apc^Min/+ X Lep^wt/wt mice (□) exposed to 0.9% NaCl, or the same genotypes exposed to PhIP (filled symbols) on (c) a 10% fat diet, or (d) a 45% fat diet. –17 mice.

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