Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Table 1

Feed and water intake in mice kept in metabolic cages for 24 h.

ob genotype	% fat diet	Gender		Feed intake (g feed/g bw/day)	Feed intake (kcal AFE/g bw/day)	n	Water intake (mL/g bw/day)
wt/wt	10	F	10	0.25 ± 0.04	0.90 ± 0.13	10	0.25 ± 0.05
		M	11	0.18 ± 0.05	0.65 ± 0.19	11	0.20 ± 0.04
ob/wt	10	F	10	0.22 ± 0.03	0.82 ± 0.12	11	0.27 ± 0.06
		M	14	0.20 ± 0.05	0.72 ± 0.18	15	0.22 ± 0.06
ob/ob	10	F	11	0.17 ± 0.04	0.62 ± 0.14	11	0.31 ± 0.16
		M	8	0.16 ± 0.02	0.59 ± 0.06	9	0.23 ± 0.10
wt/wt	45	F	12	0.10 ± 0.02	0.44 ± 0.11	12	0.18 ± 0.04
		M	13	0.07 ± 0.03	0.30 ± 0.14	8	0.13 ± 0.04
ob/wt	45	F	12	0.09 ± 0.03	0.41 ± 0.14	11	0.15 ± 0.05
		M	14	0.07 ± 0.03	0.30 ± 0.13	10	0.12 ± 0.02
ob/ob	45	F	11	0.05 ± 0.02	0.25 ± 0.07	2	0.24 ± 0.08
		M	8	0.07 ± 0.02	0.31 ± 0.08	4	0.12 ± 0.01

Feed and water intake (mean ± SD) were recorded in some of the mice from each treatment group kept in metabolic cages for 24 h at age 9–11 weeks, after they were getting accustomed to the cages the day before. There were no consistent significant differences in feed and water intake between and mice, or between 0.9% NaCl- or PhIP-treated mice, and therefore these data were pooled. F = females, M = males, and = number of mice.