Review Article

The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells

Figure 3

Under basal and inactivated conditions, perilipin 1 and CGI-58 form a complex on the surface of lipid droplets (a). On the other hand, PKA activation leads to the phosphorylation of both HSL and perilipin 1, resulting in HSL and perilipin 1 forming a complex on the surface of lipid droplets. Released CGI-58 from phosphorylated perilipin 1 binds to ATGL to induce lipolysis (b).
(a) Basal and inactivated conditions
(b) Hormone-activated conditions