The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

Figure 5

Body weight development (in gram) of female and male mice of all treatment groups is illustrated for (a) Min/+ and (b) wild-type mice from age 3-4 days to 11 weeks, and for (c) wild-type mice from age 12 to 23 weeks. The open white symbols are for untreated female mice; 10+10+10 (○), 45+10+10 (△), 10+45+10 (▽), 45+45+10 (□), 10+10+45 (◊), 45+45+45 (open hexagon), and the same filled black symbols are for untreated male mice. The PhIP-treated groups are marked with grey symbols; 45+45+10 PhIP (○) and 45+45+45 PhIP (□) in females, and 45+45+10 PhIP (△), 45+45+45 PhIP (▽) in males. The experimental groups are as explained in the legend to Figure 1. .

(a)

(b)

(c)