The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

Table 1

Effects of exposure to a 45% fat diet during various periods of life on absolute liver weight (ALW), relative liver weight (RLW), absolute spleen weight (ASW), and relative spleen weight (RSW) in female and male Min/+ mice terminated at 11 weeks of age (mean of individual mice in the group ± SD).

Experimental group		BW (g)	ALW (g)	RLW (%)	ASW (g)	RSW (%)
Min/+, females
10 + 10 + 10	22	19.4 ± 1.6	0.74 ± 0.18	3.81 ± 0.74	0.12 ± 0.03	0.65 ± 0.21
45 + 10 + 10	17	20.1 ± 1.8	0.82 ± 0.16	4.08 ± 0.58	0.12 ± 0.05	0.60 ± 0.22
10 + 45 + 10	27	21.4 ± 1.8	0.82 ± 0.11	3.84 ± 0.55	0.15 ± 0.09	0.69 ± 0.42
45 + 45 + 10	18	20.1 ± 1.7	0.82 ± 0.10	4.10 ± 0.46	0.17 ± 0.11
10 + 10 + 45	34	20.9 ± 2.6	0.75 ± 0.13	3.64 ± 0.52	0.12 ± 0.05	0.58 ± 0.22^a
45 + 45 + 45	22	23.2 ± 2.6	0.84 ± 0.14	3.66 ± 0.47^a	0.13 ± 0.05^a
45 + 45 + 10 PhIP	22	20.6 ± 2.2	0.86 ± 0.10	4.23 ± 0.54	0.21 ± 0.11	1.00 ± 0.55
45 + 45 + 45 PhIP	15	19.5 ± 2.9	0.83 ± 0.14	4.35 ± 0.84^a	0.23 ± 0.11^a	1.23 ± 0.68^c
Min/+, males
10 + 10 + 10	17	27.4 ± 2.6	1.10 ± 0.19	4.01 ± 0.55	0.12 ± 0.05^a	0.45 ± 0.21^a
45 + 10 + 10	29	27.8 ± 2.6	1.16 ± 0.16	4.16 ± 0.36^a	0.13 ± 0.07^b	0.46 ± 0.26^b
10 + 45 + 10	30	28.3 ± 2.8	1.14 ± 0.21	3.99 ± 0.55^b	0.16 ± 0.08	0.59 ± 0.31
45 + 45 + 10	19	28.8 ± 2.2		4.23 ± 0.67^c
10 + 10 + 45	25	28.0 ± 3.2	1.05 ± 0.15^a	3.78 ± 0.56	0.13 ± 0.06^c	0.48 ± 0.20^c
45 + 45 + 45	29	29.9 ± 3.2	1.07 ± 0.15^b
45 + 45 + 10 PhIP	27	25.3 ± 3.0	1.09 ± 0.14^c	4.34 ± 0.49	0.23 ± 0.11	0.94 ± 0.52
45 + 45 + 45 PhIP	29	26.5 ± 5.6	1.09 ± 0.20	4.20 ± 0.84^d	0.26 ± 0.09^e	1.00 ± 0.39^e

Relative liver weight (RLW) (%) = absolute liver weight (ALW)/body weight (BW) × 100, relative spleen weight (RSW) (%) = absolute spleen weight (ASW)/BW × 100. g = gram.
Dietary treatment groups within each gender with similar letters are significantly different.