FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population

Table 3

Association of FTO rs9939609 genotype with obesity-related traits.

Variables	Estimated change per unit A allele (95% CI)
Anthropometrics
Body weight (kg)	3.109 (0.392–5.827)	0.025
BMI (kg/m^2)	1.735 (0.89–2.579)	<0.001
WC (cm)	5.73 (3.58–7.88)	<0.001
WHR	0.068 (0.047–0.089)	<0.001
WHtR	0.041 (0.026–0.055)	<0.001
NC (cm)	2.55 (1.45–3.65)	<0.001
Overweight or obesity	0.191 (0.102–0.361)	<0.001
Central obesity	0.328 (0.151–0.714)	0.005
Central obesity	0.131 (0.068–0.253)	<0.001
Visceral obesity	0.12 (0.062–0.232)	<0.001
Energy intake (kcal/day)	354.40 (231.71–477.10)	<0.001
TSS (minutes/week)	190.52 (147.8–233.23)	<0.001
R2D : 4D	0.018 (0.011–0.025)	<0.001
L2D : 4D	0.016 (0.01–0.022)	<0.001

Data presented as beta coefficient (for continuous outcome) or odd ratio (OR) (for binary outcome) with corresponding 95% confidence interval (CI). Models were adjusted for age and sex; BMI: body mass index, NC: neck circumference, WC: waist circumference, WHR: waist to hip ratio, WHtR: waist to height ratio, R2D : 4D: ratio of the right hand second digit to the fourth, and L2D : 4D: ratio of the left hand second digit to the fourth; overweight or obesity was defined as BMI ≥ 25.0 kg/m²; central obesity was defined as WC > 80 cm for female and >94 cm for male; central obesity was defined as WHR > 0.85 for female and >0.90 for male; visceral obesity was defined as .