Interleukin-1 Receptor Antagonist and Interleukin-4 Genes Variable Number Tandem Repeats Are Associated with Adiposity in Malaysian Subjects
Table 2
Association of IL1RA and IL4 VNTRs genotype and allele distribution with demographic and anthropometric classes.
Genotypes/alleles
Gender
Ethnicity
BMI class
WC class
TBF class
Male
Female
Malay
Chinese
Indian
Nonobese
Obese
Normal
High
Normal
High
IL1RA
I/I
124 (96.9)
177 (94.7)
23 (100)
245 (97.6)
33 (80.5)
250 (95.8)
51 (94.4)
241 (96.0)
60 (93.8)
218 (98.6)
83 (88.3)
I/II
4 (3.1)
9 (4.8)
0
5 (2.0)
8 (19.5)
10 (3.8)
3 (5.6)
9 (3.6)
4 (6.2)
2 (0.9)
11 (11.7)
II/II
0
1 (0.5)
0
1 (0.4)
0
1 (0.4)
0
1 (0.4)
0
1 (0.5)
0
χ2; p
NP
I
252 (98.4)
363 (97.1)
46 (100)
495 (98.6)
74 (90.2)
510 (97.7)
105 (97.2)
491 (97.8)
124 (96.9)
438 (99.1)
177 (94.1)
II
4 (1.6)
11 (2.9)
0
7 (1.4)
8 (9.8)
12 (2.3)
3 (2.8)
11 (2.2)
4 (3.1)
4 (0.9)
11 (5.9)
p
0.30
M versus C: 1.00; M versus I: 0.05; C versus I: <0.001
0.73
0.52
0.001
IL4
B1/B1
84 (65.6)
108 (57.8)
10 (43.5)
167 (66.5)
15 (36.6)
160 (61.3)
32 (59.3)
153 (61.0)
39 (60.9)
141 (63.8)
51 (54.3)
B1/B2
31 (24.2)
57 (30.5)
11 (47.8)
67 (26.7)
10 (24.4)
74 (28.4)
14 (25.9)
69 (27.5)
19 (29.7)
60 (27.1)
28 (29.8)
B2/B2
13 (10.2)
22 (11.8)
2 (8.7)
17 (6.8)
16 (39.0)
27 (10.3)
8 914.8)
29 (11.6)
6 (9.4)
20 (9.0)
15 (16.0)
χ2; p
2.02; 0.37
NP
0.93; 0.63
0.31; 0.86
3.98; 0.14
B1
199 (77.7)
273 (73.0)
31 (67.4)
401 (79.9)
40 (48.8)
394 (75.5)
78 (72.2)
375 (74.7)
97 (75.8)
342 (77.4)
130 (69.1)
B2
57 (22.3)
101 (27.0)
15 (32.6)
101 (20.1)
42 (51.2)
128 (24.5)
30 (27.8)
127 (25.3)
31 (24.2)
100 (22.6)
58 (30.9)
χ2; p
1.82; 0.18
37.78; <0.001
0.51; 0.48
0.06; 0.80
4.75; 0.03
Parentheses indicate percentage within the same demographic/anthropometric class; NP = χ2 test not performed due presence of cell having the count of less than 5; values by χ2 or Fisher’s exact test; value significant at <0.05; values for ethnicity are combination analysis of Malay versus Chinese, Malay versus Indian, and Chinese versus Indian.
