Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding

Table 3

Metabolic pathways predicted to change by our miRNAs after LAGB. The most significant pathways () predicted by KEGG to contain genes targeted by the 6 miRNAs whose expression changed three years after LAGB.

KEGG pathways
Pathway description (ID)	FDR	miRNAs
FoxO signaling pathway (4068); AKT3, CCNB1, CDKN1A, FOXO1, PTEN, SOD2, TGFBR2		miR-519d, miR-212, miR-299-5p, miR-370
Cell cycle (4110); CCNA2, CCNB1, CDKN1A, MYC, RB1		miR-519d, miR-299-5p, miR-212
Toll-like receptor signaling pathway (4620); AKT3, IRAK4, MAP3K8, SPP1	0.000363	miR-519d, miR-299-5p, miR-212, miR-370
MAPK signaling pathway (4010); AKT3, MAP3K8, MYC, NF1, TGFBR2	0.000567	miR-519d, miR-212, miR-370
AMPK signaling pathway (4152); AKT3, CCNA2, CPT1A, FOXO1	0.000567	miR-519d, miR-212, miR-370
p53 signaling pathway (4115); CCNB1, CDKN1A, PTEN	0.00167	miR-519d, miR-299-5p, miR-212
PI3K-Akt signaling pathway (4151); AKT3, CDKN1A, MYC, PTEN, SPP1	0.00167	miR-519d, miR-299-5p, miR-212
Adipocytokine signaling pathway (4920); AKT3, CPT1A, PPARA	0.00167	miR-519d, miR-370
Tight junction (4530); AKT3, PTEN, TJP1	0.00821	miR-519d, miR-212
Focal adhesion (4510); AKT3, PTEN, SPP1	0.0259	miR-519d, miR-299-5p
mTOR signaling pathway (4150); AKT3, PTEN	0.0269	miR-519d
PPAR signaling pathway (3320); CPT1A, PPARA	0.0346	miR-370, miR-519d
Adherens junction (4520); TGFBR2, TJP1	0.0356	miR-370, miR-212
TGF-beta signaling pathway (4350); MYC, TGFBR2	0.0418	miR-212, miR-370
Apoptosis (4210); AKT3, IRAK4	0.0483	miR-519d, miR-212