A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study
Table 3
Subjects’ characteristics before and after the weight loss intervention with analyses of the changes.
Before intervention
After intervention
Change during the intervention
n
n
values
n
Body mass index (kg/m2)
42.0 (3.6)
88
38.7 (3.5)
87
<0.001#
87
Weight
123 (18)
88
113 (17)
87
<0.001#
87
Irritable bowel syndrome (IBS)
24/88 (27%)
17/88 (19%)
0.19¤
Constipation
5/24 (21%)
4/17 (24%)
0.45&
Diarrhoea
8/24 (33%)
7/17 (41%)
Mixed
11/24 (46%)
6/17 (35%)
Unsubtyped
0/24 (0%)
0/17 (0%)
Functional constipation
3/88 (3%)
8/88 (9%)
0.23¤
Functional diarrhoea
3/88 (3%)
3/88 (3%)
1.00¤
Functional bloating
14/87 (16%)
11/87 (13%)
0.66¤
IBS-severity scoring system (IBS-SSS)
116 (104)
84
81 (84)
81
77
Gastrointestinal Symptom Rating Scale-irritable bowel syndrome (GSRS-IBS) version
1.8 (0.8)
85
1.6 (0.6)
88
85
Pain syndrome
1.9 (1.1)
85
1.7 (0.9)
88
85
Bloating syndrome
2.2 (1.3)
85
1.7 (0.9)
88
85
Constipation syndrome
1.5 (0.9)
85
1.8 (1.2)
88
85
Diarrhoea syndrome
1.8 (0.9)
85
1.5 (0.7)
88
85
Satiety
1.6 (1.1)
85
1.2 (0.5)
88
85
Hopkins Symptom Checklist (HSCL-10)
1.6 (0.5)
88
1.4 (0.5)
88
<
88
WHO-5 Well-Being Index (WHO-5)
56 (19)
88
65 (14)
88
<0.001#
88
Rosenberg’s Self-Esteem Scale
2.8 (0.5)
87
3.0 (0.5)
86
0.001#
85
Fatigue Severity Scale (FSS)
37 (15)
87
34 (14)
86
0.001#
85
Epworth Sleepiness Scale
8 (5)
88
7 (5)
87
<
87
Sense of Humour Questionnaire
3.2 (0.4)
87
3.3 (0.4)
87
86
Musculoskeletal pain score
4.5 (3)
87
3.4 (3)
87
<
86
Physical activity score
4.3 (0.2)
88
4.8 (2.2)
88
88
Food tolerance (Suter)
24.0 (2.5)
85
24.2 (2.2)
88
85
Number of meals/day
4.0 (1.0)
82
4.7 (1.1)
82
<
82
LDL (1.5–4.8 mmol/L)
3.3 (0.9)
87
2.8 (0.8)
84
<0.001#
84
HDL (F: 1.0–2.7 mmol/L; M: 0.8–2.1 mmol/L)
1.2 (0.3)
87
1.1 (0.3)
85
<
84
Cholesterol (3.3–6.9 mmol/L)
5.1 (1.0)
87
4.3 (0.9)
85
<0.001#
84
CRP (<5 mg/L)
7 (6)
87
4 (4)
87
<
86
HbA1c (4.0–6.0%)
5.8 (1.1)
87
5.5 (0.8)
85
<
84
TSH (0.27–4.20 mIE/L)
1.9 (1.1)
87
1.6 (1.1)
85
84
T4 (12–22 pmol/L)
15 (3)
87
17 (7)
85
<
84
Vitamin B1 (95–200 nmol/L)
156 (23)
87
163 (30)
85
84
Vitamin B6 (15–160 nmol/L)
33 (32)
86
62 (44)
85
<
83
Vitamin B12 (140–600 pmol/L)
364 (162)
87
433 (231)
85
<
84
Vitamin D (50–150 nmol/L)
55 (21)
87
61 (26)
85
0.009#
84
The values are given as mean (SD) or n (%). LDL: low-density lipoprotein; HDL: high-density lipoprotein; CRP: C-reactive protein; TSH: thyroid-stimulating hormone; T4: thyroxin. Statistical tests with ¤McNemar’s test, &Stuart-Maxwell test, Wilcoxon signed rank test, or #paired t-test.
