Table 3: Subjects’ characteristics before and after the weight loss intervention with analyses of the changes.

Before interventionAfter interventionChange during the intervention
nn valuesn

Body mass index (kg/m2)42.0 (3.6)8838.7 (3.5)87<0.001#87
Weight123 (18)88113 (17)87<0.001#87
Irritable bowel syndrome (IBS)24/88 (27%)17/88 (19%)0.19¤
 Constipation5/24 (21%)4/17 (24%)0.45&
 Diarrhoea8/24 (33%)7/17 (41%)
 Mixed11/24 (46%)6/17 (35%)
 Unsubtyped0/24 (0%)0/17 (0%)
Functional constipation3/88 (3%)8/88 (9%)0.23¤
Functional diarrhoea3/88 (3%)3/88 (3%)1.00¤
Functional bloating14/87 (16%)11/87 (13%)0.66¤
IBS-severity scoring system (IBS-SSS)116 (104)8481 (84)8177
Gastrointestinal Symptom Rating Scale-irritable bowel syndrome (GSRS-IBS) version1.8 (0.8)851.6 (0.6)8885
 Pain syndrome1.9 (1.1)851.7 (0.9)8885
 Bloating syndrome2.2 (1.3)851.7 (0.9)8885
 Constipation syndrome1.5 (0.9)851.8 (1.2)8885
 Diarrhoea syndrome1.8 (0.9)851.5 (0.7)8885
 Satiety1.6 (1.1)851.2 (0.5)8885
Hopkins Symptom Checklist (HSCL-10)1.6 (0.5)881.4 (0.5)88< 88
WHO-5 Well-Being Index (WHO-5)56 (19)8865 (14)88<0.001#88
Rosenberg’s Self-Esteem Scale2.8 (0.5)873.0 (0.5)860.001#85
Fatigue Severity Scale (FSS)37 (15)8734 (14)860.001#85
Epworth Sleepiness Scale8 (5)887 (5)87< 87
Sense of Humour Questionnaire3.2 (0.4)873.3 (0.4)8786
Musculoskeletal pain score4.5 (3)873.4 (3)87< 86
Physical activity score4.3 (0.2)884.8 (2.2)8888
Food tolerance (Suter)24.0 (2.5)8524.2 (2.2)8885
 Number of meals/day4.0 (1.0)824.7 (1.1)82< 82
LDL (1.5–4.8 mmol/L)3.3 (0.9)872.8 (0.8)84<0.001#84
HDL (F: 1.0–2.7 mmol/L; M: 0.8–2.1 mmol/L)1.2 (0.3)871.1 (0.3)85< 84
Cholesterol (3.3–6.9 mmol/L)5.1 (1.0)874.3 (0.9)85<0.001#84
CRP (<5 mg/L)7 (6)874 (4)87< 86
HbA1c (4.0–6.0%)5.8 (1.1)875.5 (0.8)85< 84
TSH (0.27–4.20 mIE/L)1.9 (1.1)871.6 (1.1)8584
T4 (12–22 pmol/L)15 (3)8717 (7)85< 84
Vitamin B1 (95–200 nmol/L)156 (23)87163 (30)8584
Vitamin B6 (15–160 nmol/L)33 (32)8662 (44)85< 83
Vitamin B12 (140–600 pmol/L)364 (162)87433 (231)85< 84
Vitamin D (50–150 nmol/L)55 (21)8761 (26)850.009#84

The values are given as mean (SD) or n (%). LDL: low-density lipoprotein; HDL: high-density lipoprotein; CRP: C-reactive protein; TSH: thyroid-stimulating hormone; T4: thyroxin. Statistical tests with ¤McNemar’s test, &Stuart-Maxwell test, Wilcoxon signed rank test, or #paired t-test.