A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study
Table 6
Associations between the improvement in bowel symptoms and the improvement in the other variables.
IBS-severity scoring system (IBS-SSS)
Gastrointestinal Symptom Rating Scale-IBS (GSRS-IBS) version
B (95% CI)
pc
value
q value
B (95% CI)
pc
value
q value
Male gender
15.1 (−30.8; 61.1)
0.08
0.51
−0.01 (−0.38; 0.35)
0.01
0.95
Age
1.8 (−0.3; 3.9)
0.19
0.094
0.012 (−0.005; 0.029)
0.15
0.18
Body mass index
−15.2 (−27.0; −3.5)
−0.29
0.012
0.13
−0.07 (−0.17; 0.03)
−0.15
0.18
0.48
HSCL-10
23.5 (−26.9; 74.1)
0.11
0.36
0.97
0.28 (−0.11; 0.68)
0.16
0.15
0.48
WHO-5
1.3 (−0.1; 2.6)
0.22
0.059
0.43
0.011 (−0.001; 0.021)
0.23
0.038
0.42
Self-esteem
42.8 (−13.1; 98.7)
0.18
0.13
0.79
0.12 (−0.31; 0.54)
0.06
0.58
0.79
FSS
0.68 (−1.34; 2.69)
0.08
0.51
0.97
0.003 (−0.013; 0.019)
0.04
0.70
0.79
Sleepiness
−0.26 (−5.46; 4.94)
−0.01
0.92
0.97
0.02 (−0.022; 0.062)
0.10
0.35
0.60
Sense of humour
74.7 (17.9; 131.4)
0.30
0.012
0.13
0.35 (−0.11; 0.81)
0.17
0.14
0.48
Musculoskeletal pain
0.18 (−0.20; 9.55)
0.01
0.97
0.97
0.012 (−0.061; 0.084)
0.04
0.75
0.79
Physical activity
4.09 (−3.15; 11.33)
0.13
0.26
0.73
−0.013 (−0.068; 0.043)
−0.05
0.65
0.79
Number of meals/day
0.05 (−0.07; 0.16)
0.09
0.44
0.97
0.11 (−0.03; 0.01)
0.16
0.16
0.48
Food tolerance
3.02 (5.67; 11.70)
0.08
0.49
0.97
0.04 (−0.03; 0.10)
0.12
0.31
0.60
LDL
8.8 (−24.8; 42.4)
0.06
0.60
0.97
0.10 (−0.17; 0.37)
0.08
0.46
0.72
HDL
−11.0 (−110.6; 88.6)
−0.03
0.83
0.97
−0.75 (−1.54; 0.04)
−0.21
0.061
0.45
Cholesterol
3.0 (−26.4; 32.4)
0.03
0.84
0.97
0.12 (−0.13; 0.36)
0.11
0.35
0.60
CRP
−0.4 (−4.7; 4.0)
−0.02
0.87
0.97
0.003 (−0.033; 0.039)
0.02
0.87
0.87
HbA1c
−8.2 (−40.9; 24.4)
−0.06
0.62
0.97
−0.08 (−0.35; 0.19)
−0.07
0.54
0.79
TSH (decrease)
3.1 (−15.2; 21.4)
0.04
0.74
0.97
0.02 (−0.12; 0.17)
0.04
0.74
0.79
T4 (increase)
0.7 (−2.2; 3.6)
0.06
0.63
0.97
0.004 (−0.020; 0.028)
0.04
0.75
0.79
Vitamin B1
0.24 (−0.51; 0.99)
0.08
0.53
0.97
0.005 (−0.001; 0.011)
0.17
0.13
0.48
Vitamin B6
−0.01 (−0.49; 0.47)
−0.01
0.97
0.97
0.002 (−0.002; 0.006)
0.14
0.23
0.51
Vitamin B12
−0.01 (−0.15; 0.14)
−0.01
0.91
0.97
0.0005 (0.0003; 0.0014)
0.14
0.21
0.51
Vitamin D
0.52 (−0.43; 1.46)
0.13
0.28
0.97
0.010 (−0.002; 0.017)
0.29
0.010
0.22
HSCL-10: Hopkins Symptom Checklist 10; WHO-5: World Health Organization 5 Well-Being Index; FSS: Fatigue Severity Scale; LDL: low-density lipoprotein; HDL: high-density lipoprotein; CRP: C-reactive protein; TSH: thyroid-stimulating hormone; T4: thyroxin. Linear regression with IBS-SSS and GSRS-IBS as the independent variables, and the other variables one by one as covariates, adjusted for gender and age (gender and age presented unadjusted in the first two rows). q values are Benjamini-Hochberg adjusted to preserve false discovery rate for twenty-two hypotheses.
