Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

Table 4

Measures of the fibrin clot structure and fibrinolytic activity at baseline and at 3 and 6 months.

	CON	n^b	BIKE	n^b	MOD	n^b	VIG	n^b	values
Vmax (OD/min)									0.189^c, 0.495^d, 0.567^e
Baseline	0.80 (0.72; 0.89)	15	0.76 (0.70; 0.83)	15	0.86 (0.77; 0.95)	28	0.76 (0.69; 0.84)	22
3 months	0.80 (0.72; 0.88)	15	0.76 (0.69; 0.83)	15	0.80 (0.72; 0.88)	28	0.75 (0.68; 0.81)	22
6 months	0.83 (0.74; 0.91)	15	0.76 (0.65; 0.87)	15	0.77 (0.69; 0.85)	28	0.77 (0.70; 0.83)	22
Clot lysis (%)									0.714^c, 0.476^d, 0.061^e
Baseline	38.0 (29.5; 46.4)	15	37.5 (31.2; 43.8)	15	44.4 (39.5; 49.2)	28	38.9 (33.5; 44.3)	22
3 months	36.9 (28.8; 45.1)	15	37.7 (30.5; 44.8)	15	48.1 (42.3; 54.0)	28	39.1 (32.8; 45.3)	22
6 months	36.3 (27.7; 44.8)	15	35.4 (28.0; 42.7)	15	45.2 (40.0; 50.7)	28	39.3 (32.4; 46.2)	22
Fiber mass-length ratio (×10^12 Da/cm)									0.292^c, 0.501^d, 0.788^e
Baseline	6.76 (6.18; 7.34)	15	7.05 (6.57; 7.54)	15	7.19 (6.73; 7.64)	28	6.86 (6.35; 7.36)	22
3 months	6.85 (6.46; 7.23)	15	7.04 (6.45; 7.63)	15	6.96 (6.50; 7.43)	28	7.02 (6.42; 7.63)	22
6 months	6.87 (6.18; 7.56)	15	7.26 (6.24; 8.28)	15	6.85 (6.50; 7.21)	28	7.49 (6.80; 8.18)	22
Fiber diameter (µm)									0.117^c, 0.883^d, 0.761^e
Baseline	0.14 (0.13; 0.15)	15	0.14 (0.13; 0.15)	15	0.14 (0.14; 0.15)	28	0.14 (0.13; 0.15)	22
3 months	0.14 (0.14; 0.15)	15	0.14 (0.13; 0.15)	15	0.14 (0.13; 0.14)	28	0.14 (0.13; 0.15)	22
6 months	0.14 (0.14; 0.15)	15	0.13 (0.12; 0.14)	15	0.14 (0.13; 0.14)	28	0.14 (0.13; 0.15)	22
Fiber mass density (×10^22 Da/cm^3)									0.476^c, 0.414^d, 0.466^e
Baseline	4.53 (4.20; 4.85)	15	5.01 (4.06; 5.97)	15	4.54 (4.33; 4.74)	28	4.54 (4.31; 4.76)	22
3 months	4.33 (4.14; 4.52)	15	4.47 (4.25; 4.69)	15	4.68 (4.43; 4.92)	28	4.62 (4.40; 4.85)	22
6 months	4.30 (4.06; 4.54)	15	5.28 (4.36; 6.20)	15	4.66 (4.48; 4.85)	28	4.75 (4.30; 5.19)	22
Fibrinolytic activity (IU/ml)^a									0.878^c, 0.960^d, 0.123^e
Baseline	78 (52; 117)	15	113 (73; 175)	15	71 (56; 91)	29	94 (69; 130)	22
3 months	76 (54; 106)	15	115 (81; 163)	15	73 (55; 96)	29	93 (69; 124)	22
6 months	78 (54; 112)	15	94 (64; 137)	15	76 (61; 95)	29	99 (73; 133)	22

Data are unadjusted mean (95% CI) or ^ageometric mean (geometric 95% CI); ^bnumber of samples available for analysis; ^c values for interactions between the group and time; ^d values for main effects of time for all groups combined; ^e values for between-group effects; CON, control group; BIKE, active commuting exercise group; MOD, moderate-intensity leisure-time exercise group; VIG, vigorous-intensity leisure-time exercise group; OD, optical density.