Figure 4: Proposed molecular mechanism of cardioprotection by omega-3 PUFAs. Omega-3 PUFAs modulate platelet cell membrane property when incorporated into the phospholipid bilayer and control membrane ion channels to prevent lethal arrhythmia. Also, omega-3 PUFAs exert anti-inflammatory and antifibrotic effects by modifying NF-κB signaling, the NLRP3 inflammasome, PPARα/γ, GPR120, and TGF-β signaling (from reference [71]).