Journal of Obesity / 2020 / Article / Tab 4

Research Article

Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity

Table 4

Interaction between SSB intake and SNPs in 10 genes of PC/PE biosynthetic pathways on BMI.

GeneSNPChrPosition-interactionFDRBeta (GxE)#SE (BetaGxE)Minor/MajorMAF

CEPT1rs1274582711117000011.44E − 031.71E − 021.7460.547G/T0.074
CHKBrs7518758722510191131.47E − 056.10E − 042.5220.580C/A0.050
CHKBrs8633722510206682.03E − 032.11E − 02−1.0170.329C/A0.375
CHKBrs600993122510231527.50E − 034.44E − 021.4440.539G/T0.076
ETNK1rs1742752012228335182.76E − 045.73E − 032.0480.561C/T0.021
ETNK1rs227109712228372822.87E − 032.97E − 021.7970.602G/A0.040
ETNK2rs110677812041155487.84E − 063.25E − 041.3990.312T/C0.462
ETNK2rs495131312041229781.07E − 031.48E − 02−1.0120.309G/A0.371
PCYT1Ars6158844331960133184.82E − 033.33E − 020.8890.315G/A0.262
PEMTrs7282848017174428543.34E − 072.77E − 053.5480.692T/C0.031
PEMTrs212434417174801951.17E − 031.39E − 021.2620.388A/G0.363
PEMTrs6663705917174178089.34E − 041.55E − 021.5570.469T/C0.118
PISDrs1170380822320249804.21E − 033.18E − 020.9530.332G/A0.479

-interaction: values of interaction between SNP and SSB intake on BMI. #Beta(GxE): beta of interaction between SNP and SSB model adjusted for age, sex, smoking, alcohol use, physical activity score, and population structure. MAF: minor allele frequency; FDR: false discovery rate; sample size: n = 1311.

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