Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
Table 4
Interaction between SSB intake and SNPs in 10 genes of PC/PE biosynthetic pathways on BMI.
Gene
SNP
Chr
Position
-interaction
FDR
Beta (GxE)#
SE (BetaGxE)
Minor/Major
MAF
CEPT1
rs12745827
1
111700001
1.44E − 03
1.71E − 02
1.746
0.547
G/T
0.074
CHKB
rs75187587
22
51019113
1.47E − 05
6.10E − 04
2.522
0.580
C/A
0.050
CHKB
rs86337
22
51020668
2.03E − 03
2.11E − 02
−1.017
0.329
C/A
0.375
CHKB
rs6009931
22
51023152
7.50E − 03
4.44E − 02
1.444
0.539
G/T
0.076
ETNK1
rs17427520
12
22833518
2.76E − 04
5.73E − 03
2.048
0.561
C/T
0.021
ETNK1
rs2271097
12
22837282
2.87E − 03
2.97E − 02
1.797
0.602
G/A
0.040
ETNK2
rs1106778
1
204115548
7.84E − 06
3.25E − 04
1.399
0.312
T/C
0.462
ETNK2
rs4951313
1
204122978
1.07E − 03
1.48E − 02
−1.012
0.309
G/A
0.371
PCYT1A
rs61588443
3
196013318
4.82E − 03
3.33E − 02
0.889
0.315
G/A
0.262
PEMT
rs72828480
17
17442854
3.34E − 07
2.77E − 05
3.548
0.692
T/C
0.031
PEMT
rs2124344
17
17480195
1.17E − 03
1.39E − 02
1.262
0.388
A/G
0.363
PEMT
rs66637059
17
17417808
9.34E − 04
1.55E − 02
1.557
0.469
T/C
0.118
PISD
rs11703808
22
32024980
4.21E − 03
3.18E − 02
0.953
0.332
G/A
0.479
-interaction: values of interaction between SNP and SSB intake on BMI. #Beta(GxE): beta of interaction between SNP and SSB model adjusted for age, sex, smoking, alcohol use, physical activity score, and population structure. MAF: minor allele frequency; FDR: false discovery rate; sample size: n = 1311.
