Table of Contents
Journal of Oral Oncology
Volume 2014 (2014), Article ID 238698, 5 pages
http://dx.doi.org/10.1155/2014/238698
Clinical Study

Head and Neck Solitary Extramedullary Plasmacytoma

1Shiraz Institute for Cancer Research, Department of Otolaryngology and Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz 71936-13511, Iran
2Student Research Committee, Department of Otolaryngology and Head and Neck Surgery, Khalili Hospital Shiraz University of Medical Sciences, Shiraz 71936-13511, Iran
3Colorectal Research Center, Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz 71936-13511, Iran
4Student Research Committee, Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz 71936-13511, Iran
5Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz 71447-16699, Iran

Received 3 April 2013; Accepted 19 December 2013; Published 4 February 2014

Academic Editor: Enver Ozer

Copyright © 2014 Bijan Khademi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. This study aimed to report the characteristics and treatment outcome of 13 patients with solitary extramedullary plasmacytomas of the head and neck and analytical literature review. Materials and Methods. Nine patients (69%) were treated with gross surgical resection followed by radiotherapy, three (23%) were primarily treated with radiotherapy alone, and one (8%) was treated with surgery alone. Results. There were 3 women and 10 men with the median age of 52 years. Nasal cavity (46%) and paranasal sinuses (23%) were the most common primary sites. After a median follow-up of 28 months, 10 patients are alive and free of disease, one is alive with multiple myeloma, and two died of multiple myeloma. In the literature review the median age was 58 years and male/female ratio was 2.7. Sinonasal tract was the most common primary site. Ten-year local control and progression to multiple myeloma rates were 88% and 23%, respectively. The 5- and the 10-year overall survival rates were 71 and 69%, respectively. Conclusion. Radiation therapy with or without surgery is an effective treatment for patients with head and neck extramedullary plasmacytoma. However, long-term follow-up for detection of local recurrence and progression to multiple myeloma is essential.