Table of Contents
Journal of Oral Oncology
Volume 2014, Article ID 864230, 5 pages
http://dx.doi.org/10.1155/2014/864230
Clinical Study

A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer

1Genetic Division, Department of Anatomy, Mahatma Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry 607 402, India
2Department of Pathology, Mahatma Medical College and Research Institute, Sri Balaji Vidyapeeth, Pondicherry 607 402, India

Received 31 May 2014; Revised 3 September 2014; Accepted 30 September 2014; Published 1 December 2014

Academic Editor: Takashi Saku

Copyright © 2014 A. N. Uma and Dhananjay S. Kotasthane. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, I. Soerjomataram, M. Ervik et al., GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base, International Agency for Research on Cancer, Lyon, France, No. 11, 2013, http://globocan.iarc.fr/.
  2. J. S. Yadav, S. Thakur, and P. Chadha, “Chyawanprash awaleha: a genoprotective agent for Bidi smokers,” International Journal of Human Genetics, vol. 3, no. 1, pp. 33–38, 2003. View at Google Scholar
  3. S. C. Sthanam, Commentary by RK Sharma, Choukhambha Sanskrit Series Office, Bhagwan Dash, Varanasi, India, 1st edition, 1988.
  4. M. A. Ferguson-Smith, S. D. Handmaker, and A. B. J. Hopkins, “Observation on the satellite human chromosomes,” The Lancet, vol. 277, no. 7178, pp. 638–640, 1961. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Ohno, J. M. Trujillo, W. D. Kaplan, R. Kinosita, and C. Stenius, “Nucleolus organizers in the causation of chromosomal anomalies in man,” The Lancet, vol. 278, no. 7194, pp. 123–126, 1961. View at Publisher · View at Google Scholar · View at Scopus
  6. T. C. Hsu, F. E. Arrighi, R. R. Klevecz, and B. R. Brinkley, “The nucleoli in mitotic divisions of mammalian cells in vitro,” Journal of Cell Biology, vol. 26, no. 2, pp. 539–553, 1965. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Hansson and M. Mikkelson, “An increased tendency to satellite association of human chromosome 21: a factor in the etiology of Down’s syndrome,” International Research Communications System Journal of Medical Science, vol. 2, p. 1617, 1974. View at Google Scholar
  8. N. Anuradha, M. Satyanarayana, and K. R. Manjunatha, “Satellite associations in recurrent aborters,” International Journal of Human Genetics, vol. 2, pp. 61–64, 2002. View at Google Scholar
  9. J. S. Yadav, S. Thakur, and A. K. Chillar, “Genetic risk assessment in cigarette smokers,” Journal of Human Ecology, vol. 10, pp. 165–170, 2001. View at Google Scholar
  10. D. A. Hungerford, “Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl,” Stain Technololgy, vol. 40, pp. 333–338, 1965. View at Google Scholar
  11. A. Hansson, “A differences in the satellite association pattern in the human population,” Hereditas, vol. 66, pp. 21–30, 1970. View at Google Scholar
  12. A. N. Uma, R. Pajanivel, S. Raj, and Lokeshmaran, “Smoking-induced satellite associations in a rural population of south India: an in vitro study,” International Journal of Applied and Basic Medical Research, vol. 2, pp. 75–79, 2011. View at Google Scholar
  13. J. S. Yadav and S. Thakur, “Genetic risk assessment in hookah smokers,” Cytobios, vol. 101, pp. 101–103, 2000. View at Google Scholar · View at Scopus
  14. J. S. Yadav and S. Thakur, “Cytogenetic damage in bidi smokers,” Nicotine & Tobacco Research, vol. 2, no. 1, pp. 97–103, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. H. F. Stich and W. Stich, “Chromosome-damaging activity of saliva of betel nut and tobacco chewers,” Cancer Letters, vol. 15, no. 1, pp. 193–202, 1982. View at Google Scholar
  16. V. Ramakrishnan, S. Gowtham Kumar, and S. Govindaraju, “Cytogenetic analysis of micronuclei, sister chromatid exchange and chromosomal aberrations in pan masala chewers,” International Journal of Pharma and Bio Sciences, vol. 2, no. 3, pp. B122–B134, 2011. View at Google Scholar · View at Scopus
  17. M. Fareed, M. Afzal, and Y. H. Siddique, “Micronucleus investigation in buccal mucosal cells among pan masala/gutkha chewers and its relevance for oral cancer,” Biology and Medicine, vol. 3, no. 2, pp. 8–15, 2011. View at Google Scholar · View at Scopus
  18. J. K. Jose and R. Kuttan, “Inhibition of oxygen free radicals by Emblica officinalis extract and Chyawanprash,” Amla Research Bulletin, vol. 15, pp. 46–52, 1995. View at Google Scholar
  19. W. A. Pryor, “Cigarette smoke and the involvement of free radical reactions in chemical carcinogenesis,” British Journal of Cancer, vol. 55, pp. 19–23, 1987. View at Google Scholar
  20. P. A. Cerutti, “Prooxidant states and tumor promotion,” Science, vol. 227, no. 4685, pp. 375–381, 1985. View at Publisher · View at Google Scholar · View at Scopus
  21. K. J. Shamberger, E. Rukovena, A. K. Longfield et al., “Carcinogenic and mutagenic metal compounds,” Journal of the National Cancer Institute, vol. 50, p. 863, 1973. View at Google Scholar
  22. A. Deepa Das, A. Balan, and K. Y. Sreelatha, “Comparative study of the efficacy of curcumin and turmeric oil as chemopreventive agents in oral submucous fibrosis: a clinical and histopathological evaluation,” Journal of Indian Academy of Oral Medicine and Radiology, vol. 22, no. 2, pp. 88–92, 2010. View at Google Scholar
  23. H. Garewal, “Antioxidants in oral cancer prevention,” The American Journal of Clinical Nutrition, vol. 62, no. 6, supplement, pp. 1410S–1416S, 1995. View at Google Scholar · View at Scopus
  24. L. Kohlmeier, N. Simonsen, and K. Mottus, “Dietary modifiers of carcinogenesis,” Environmental Health Perspectives, vol. 103, supplement 8, pp. 177–184, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. J. K. Ojha, H. S. Bajpai, P. V. Sharma, A. S. Khanna Bodhade, and A. M. Dive, “Chemoprevention of premalignant and malignant lesions of oral cavity: recent trends,” European Journal of Dentistry, vol. 7, pp. 246–250, 2013. View at Google Scholar
  26. B. Das, “Antioxidants in the treatment & prevention of oral cancer,” Kerala Dental Journal, vol. 1, no. 4, 2008. View at Google Scholar
  27. S. M. Khopde, K. Indira Priyadarshini, H. Mohan et al., “Characterizing the antioxidant activity of amla (Phyllanthus emblica) extract,” Current Science, vol. 81, no. 2, pp. 185–109, 2001. View at Google Scholar
  28. J. K. Ojha, Chyawanprash—A Scientific Study, Tara Book Agency, Varanasi, India, 1st edition, 1988.
  29. T. G. Shrihari, V. Vasudevan, S. Kailasam, D. Devaiah, V. Manjunath, and G. R. Jagadish, “Antioxidants: are we abusing it?” Journal of Indian Academy of Oral Medicine & Radiology, vol. 24, no. 4, pp. 306–310, 2012. View at Google Scholar