Review Article
Risk Factors for Age-Related Maculopathy
Table 17
Studies investigating the relationship between iris color and risk for ARM.
| Study | No. of cases | Measure of risk factor | Type of ARM | Odds ratio or relative risk | 95% confidence interval |
| Cross-Sectional Studies | | | | | |
| Copenhagen City Eye Study [269] | 924 | Brown versus blue iris color | Drusen and decreased vision | 0.7 | N/A |
|
Blue Mountains Eye Study [270] | 3654 | Blue versus brown iris colour | Early ARM | 1.45 | 1.1–1.9 | Late ARM | 1.69 | 1.0–2.9 | Early ARM | 1.06 | 0.76–1.47 (Right eye) | 1.15 | 0.85–1.56 (Left eye) |
| Prospective Studies | | | | | |
|
Beaver Dam Eye Study [271] | 3684 | Brown iris Color | Late ARM | 1.61 | 0.60–4.33 (Right eye) | 0.99 | 0.41–2.37 (Left eye) |
|
Beaver Dam Eye Study [271] | 2764 | Blue versus brown iris color | Soft indistinct drusen | 1.53 | 1.19–1.97 | Retinal pigment abnormalities | 0.58 | 0.41–0.82 |
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