Risk Factors for Age-Related Maculopathy

Table 18

Studies investigating the relationship between cataract and risk for ARM.

Study	No. of cases	Measure of risk factor	Type of ARM	Odds ratio or relative risk	95% confidence interval
Cross-Sectional Studies
Framingham Eye Study [52, 53]		Nuclear sclerosis	Early and late ARM	<1.00 (All ages)	N/A
		Cortical lens opacity	Early and late ARM	>1.00 (Age 52–74)	N/A
National Health and Nutrition Examination Survey I [54]	3087	Opacity without visual impairment	ARM	1.80	1.40–2.30
		Cataract	ARM	1.14	0.84–1.55
Blue Mountains Eye Study [272]	3654	Nuclear Sclerosis	Early ARM	1.0	0.6–1.9
			Late ARM	1.6	0.5–5.3
		Cortical lens Opacity	Early ARM	1.4	0.9–2.2
			Late ARM	1.7	0.7–4.2
		Posterior Subcapsular lens Opacity	Early ARM	1.1	0.4–2.7
			Late ARM	3.0	1.0–9.3
Beaver Dam Eye Study [273]	4926	Nuclear sclerosis	Early ARM	1.96	1.28–3.01
			Late ARM	1.38	0.52–3.63
ProspectiveStudies
Beaver Dam Eye Study [181, 273, 274]	2764	Any lens opacity	Early ARM	1.30	1.04–1.63
Copenhagen City Eye Study [38–40]	359	Any lens opacity	Early and late ARM	2.8	1.2–6.2