Review Article

Risk Factors for Age-Related Maculopathy

Table 2

Risk factors for ARM examined in the cited studies.

Genetic predisposition

Family history of ARM
Complement Factor H gene
Apolipoprotein E gene
LOC gene

Cardiovascular disease

Clinical Evidence of Atherosclerosis
Angina/Heart attack/Stroke
Subclinical evidence of atherosclerosis
Carotid atherosclerosis
Aortic atherosclerosis
Cigarette smoking
Diabetes mellitus
Hypertension and associated disease
Ischemic cerebral white matter changes
Abnormalities of the retinal vasculature
Cholesterol
Total cholesterol
Low-density Lipoprotein (LDL) cholesterol
High-density Lipoprotein (HDL) cholesterol
Obesity
Female sex hormones
Endogenous estrogen exposure
Age at menarche
Age at menopause
Number of pregnancies
Exogenous estrogen exposure
Oral contraceptives
Hormone replacement therapy
Novel risk factors for atherosclerosis
Lipid-related Factors
Apolipoproteins
Lipoproteins
Inflammatory markers
C-reactive protein
Interleukins
Serum Amyloid A
Vascular and Cellular Adhesion Molecules
White Blood Cell Count
Homocysteine/Folate/Vitamin B12/Vitamin B6
Infectious agents
Cytomegalovirus
Helicobacter pylori
Chlamydia pneumoniae

Indicators of Inflammation

Systemic Diseases with Inflammatory Components
Gout
Emphysema
Anti-inflammatory Medications
NSAIDs
Steroids
Markers of Systemic Inflammation
White Blood Cell Count
Serum Albumin
Plasma Fibrinogen
C-reactive Protein
Complement Factor H Y402H Polymorphism
CRP Haplotype
Serum Amyloid A
Interleukin-6
Tumor Necrosis Factor- 𝛼

Markers of Endothelial Dysfunction

Intercellular Adhesion Molecule-1
E-Selectin

Indicators of Oxidative Stress

Anti-oxidants
Vitamin C
Vitamin E
Vitamin A
Carotenoids
Lutein
Zeaxanthin
𝛼 - and 𝛽 -Carotene
𝛽 -Cryptoxanthin
Lycopene
Enzymes
Plasma Glutathione Peroxidase
Superoxide Dismutase
Trace Elements
Zinc
Pro-oxidant status
Dietary fat intake
Total fat
Saturated fat
Polyunsaturated fat
Fish/Fish oils
Visible Light Exposure
Sunlight
Ultraviolet-B

Ocular Factors

Refractive Error
Emmetropia
Myopia
Hypermetropia
Iris Color
Cataract
Nuclear Sclerosis
Cortical Lens Opacities
Posterior Subcapsular Cataracts
Cataract Surgery

Miscellaneous Factors

Alcohol Consumption
Beer
Wine
Spirits
Medication Use
Estrogens
Lipid-lowering Agents
CNS Medications
Non-steroidal Anti-Inflammatory Medications
Anti-hypertensive Medications
Coffee Consumption
Frailty
Physical Activity