Review Article
Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat
Table 1
Ocular pathological findings in diabetic human, SDT rats, and STZ-induced diabetic rats.
| | Human | SDT rats | STZ rats |
| | Retina | | | | | Hyperpermeability | Yes | Yes | Yes | | Retinal detachment | Yes | Yes | No | | Retinal thickness | Yes | Yes | Yes | | Avascular area | Yes | No | No | | Neovascularization | Yes | Yes | Yes | | Retinal microaneurysm | Yes | No | No | | Pericyte loss | Yes | Yes | Yes | | Vessel abnormality | Yes | Yes | Yes | | VEGF expression | High | High | High | | PEDF expression | Low | High | High | | Vitreous body | | | | | Proliferative membrane | Yes | Yes | No | | Iris | | | | | Neovascularization | Yes | Yes | No | | Lens | | | | | Cataract | Yes | Yes | Yes | | (senile cataract true diabetic cataract) | (true diabetic cataract) | (true diabetic cataract) |
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