Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas

Table 2

Top 10 single-marker associations with severe diabetic retinopathy among Mexican-Americans from Starr County, Texas.

dbSNP rs#	Chr	${\text{Position}}^{*}$	Minor/major allele	MAF in Cases	MAF in Controls	$P$-${\text{value}}^{\S }$	${\text{OR}}^{+}$ (95%CI)	Nearest ${\text{gene}}^{*}$	Distance/; relationship to gene
rs2300782	5	110816684	A/G	0.512	0.322	$6.04E-05$	2.64 (1.64–4.25)	CAMK4	intron/0
rs10519765	15	30992716	A/G	0.136	0.294	$6.21E-05$	0.30 (0.16–0.54)	FMN1	intron/0
rs899036	11	41639486	C/A	0.125	0.210	$2.52E-04$	0.32 (0.17–0.59)	API5	upstream/; 1650623
rs10501943	11	99452209	C/T	0.195	0.086	$2.53E-04$	3.04 (1.68–5.52)	CNTN5	intron/0
rs1445754	5	83611387	A/T	0.143	0.273	$3.35E-04$	0.37 (0.22–0.64)	EDIL3	intron/0
rs1197310	3	134610914	T/A	0.540	0.435	$3.35E-04$	2.25 (1.45–3.51)	BFSP2	intron/0
rs699549	2	4683138	T/C	0.115	0.043	$3.49E-04$	4.27 (1.93–9.47)	—	—
rs763970	2	138352603	A/C	0.330	0.206	$4.00E-04$	2.25 (1.44–3.52)	HNMT	upstream/; 85675
rs599019	18	284495	G/T	0.030	0.131	$4.06E-04$	0.15 (0.05–0.43)	COLEC12	downstream/; 24861
rs6427247	1	168647104	G/A	0.360	0.221	$4.56E-04$	2.17 (1.41–3.35)	SCYL1BP1	upstream/; 120790

${}^{*}$Affymetrix NetAffx annotation build 25, NCBI genome build 36.1.
${}^{\S }P$-value of logistic regression under additive genetic model, adjusted for age, gender, diabetes duration, and HbA1c level.
${}^{+}$odds ratios of the minor allele.