Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside
Figure 2
A schematic diagram illustrates the interaction of Complex I dysfunction, decreased ATP production, increased ROS, and apoptosis that culminate in the optic nerve degeneration of LHON and LHON cellular and animal models. ATP—adenosine triphosphate; ROS—reactive oxygen species.
