Review Article

Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection

Figure 1

Model of the gp130-STAT3-SOCS3 pathway. IL-6 family ligands activate the gp130 receptor, which subsequently phosphorylates and activates STAT3 through JAK. Activated and dimerized STAT3 translocates into the nucleus to promote the transcription of various molecules, including SOCS3 and IL-6. SOCS3 inhibits JAK and STAT3 activation. IL-6 is secreted and further activates STAT3.
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