TY - JOUR A2 - Leung, Christopher AU - Machida, Shigeki AU - Tamada, Kunifusa AU - Oikawa, Taku AU - Gotoh, Yasutaka AU - Nishimura, Tomoharu AU - Kaneko, Muneyoshi AU - Kurosaka, Daijiro PY - 2011 DA - 2010/09/30 TI - Comparison of Photopic Negative Response of Full-Field and Focal Electroretinograms in Detecting Glaucomatous Eyes SP - 564131 VL - 2011 AB - Purpose. To compare the photopic negative response (PhNR) of the full-field electroretinogram (ERG) to the PhNR of the focal ERGs in detecting glaucoma. Methods. One hundred and three eyes with glaucoma and 42 normal eyes were studied. Full-field ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15 white stimulus spot centered on the macula, the superotemporal or the inferotemporal areas of the macula. Results. In early glaucoma, the areas under the receiver operating characteristic curves (AUCs) were significantly larger for the focal PhNR (0.863–0.924) than those for the full-field PhNR (0.666–0.748) (P<.05). The sensitivity was significantly higher for the focal PhNR than for the full-field PhNR in early (P<.01) and intermediate glaucoma (P<.05). In advanced glaucoma, there was no difference in the AUCs and sensitivities between the focal and full-field PhNRs. Conclusions. The focal ERG has the diagnostic ability with higher sensitivity in detecting early and intermediate glaucoma than the full-field ERG. SN - 2090-004X UR - https://doi.org/10.1155/2011/564131 DO - 10.1155/2011/564131 JF - Journal of Ophthalmology PB - Hindawi Publishing Corporation KW - ER -