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Journal of Ophthalmology
Volume 2012, Article ID 107053, 6 pages
Clinical Study

Comparison of Retinal Nerve Fiber Layer Thickness Measurements in Healthy Subjects Using Fourier and Time Domain Optical Coherence Tomography

1Ophthalmology Department, Lozano Blesa University Hospital, c/ San Juan Bosco 15, 50009 Zaragoza, Spain
2Aragones Institute of Health Science, IIS Aragon, C/ Gómez Laguna 25, 50009 Zaragoza, Spain
3Ophthalmology Department, Miguel Servet University Hospital, c/ Isabel la Católica 1-3, 50009 Zaragoza, Spain

Received 3 February 2012; Accepted 6 March 2012

Academic Editor: Robert J. Zawadzki

Copyright © 2012 Isabel Pinilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To compare the retinal nerve fiber layer (RNFL) measurements using two different ocular coherence tomography (OCT) devices: Cirrus Fourier domain OCT and Stratus time domain OCT. To analyze reproducibility of Fourier domain measurements in healthy subjects. Methods. One hundred and thirty-two eyes of 132 healthy subjects were scaned on the same day with both instruments, separated by 10 minutes from each other. Thickness of quadrant, average and the 12 different areas around the optic nerve were compared between Cirrus and Stratus. Repeatability, intraclass correlation coefficients (ICCs), and coefficients of variation (COVs) were calculated in RNFL measurements provided by Fourier domain device. Results. The average thickness in the optic cube was 95.50 μm using Cirrus and 97.85 μm using Stratus. Average thickness and temporal quadrant showed significant differences using Cirrus and Stratus methods. Reproducibility was better with Fourier domain OCT (mean COV of 4.54%) than with Stratus time-domain OCT (mean COV of 5.57%). Conclusions. Both scan options give reproducible RNFL thickness measurement, but there are differences between them. Measurements obtained using Fourier domain device show better reproducibility.