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Journal of Ophthalmology
Volume 2012, Article ID 429387, 4 pages
Review Article

In Vivo Molecular Imaging in Retinal Disease

1Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Received 22 September 2011; Accepted 1 December 2011

Academic Editor: Ofra Benny

Copyright © 2012 Fang Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of ocular fundus vasculature. To detect endothelial injury at the early and reversible stage of adhesion molecule upregulation, some novel imaging agents that target retinal endothelial molecules were generated. In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current preclinical findings and advances in instrumentation such as endoscopes and microcatheters suggest that these molecular imaging modalities have numerous clinical applications and will be translated into clinical use in the near future.