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Journal of Ophthalmology
Volume 2012, Article ID 484612, 6 pages
Review Article

Combination Therapy for Diabetic Macular Edema

Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel

Received 1 August 2011; Accepted 25 December 2011

Academic Editor: Chi-Chao Chan

Copyright © 2012 Dinah Zur and Anat Loewenstein. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic macular edema is a main reason for visual loss in diabetic patients. Until recent years, macular laser photocoagulation was the only available therapy. The awareness that inflammation is an important factor in the pathogenetic process of DME gave reason for intravitreal treatment with corticosteroids. The introduction of anti-VEGF drugs brought a revolutionary change in the treatment of DME. This paper will review the important clinical trials with an emphasis on combination therapies.