Research Article

Safety and Efficacy of Epithelium-On Corneal Collagen Cross-Linking Using a Multifactorial Approach to Achieve Proper Stromal Riboflavin Saturation

Table 1

Visual acuity, refraction, and corneal thickness changes during 1-year followup.

ParameterPreoperative ( 𝑛 = 6 1 )Postoperative
1 Month ( 𝑛 = 5 9 )3 Months ( 𝑛 = 2 9 )6 Months ( 𝑛 = 3 3 )12 Months ( 𝑛 = 6 1 )

VA (Snellen)
 UDVA ( 2 0 / 1 3 3 ± 2 0 / 5 7 ) ( 2 0 / 9 5 ± 2 0 / 4 9 ) ( 𝑃 = 0 . 0 0 ) ( 2 0 / 8 7 ± 2 0 / 4 4 ) ( 𝑃 = 0 . 0 0 ) ( 2 0 / 8 0 ± 2 0 / 4 8 ) ( 𝑃 = 0 . 0 0 ) ( 2 0 / 6 7 ± 2 0 / 4 2 ) ( 𝑃 = 0 . 0 0 )
 CDVA ( 2 0 / 3 2 ± 2 0 / 3 3 ) ( 2 0 / 2 9 ± 2 0 / 3 0 ) ( 𝑃 = 0 . 0 1 ) ( 2 0 / 2 8 ± 2 0 / 3 1 ) ( 𝑃 = 0 . 0 0 ) ( 2 0 / 2 6 ± 2 0 / 3 0 ) ( 𝑃 = 0 . 0 0 ) ( 2 0 / 2 4 ± 2 0 / 2 8 ) ( 𝑃 = 0 . 0 0 )
Refraction (D)
 Sphere 0 . 0 5 ± 3 . 0 3 0 . 6 4 ± 3 . 1 4
( 𝑃 = 0 . 1 2 )
0 . 4 4 ± 2 . 8 2
( 𝑃 = 0 . 5 5 )
0 . 5 0 ± 2 . 9 2
( 𝑃 = 0 . 1 0 )
0 . 2 1 ± 2 . 4 3
( 𝑃 = 0 . 6 1 )
 SE 1 . 9 7 ± 3 . 1 9 0 . 9 8 ± 3 . 0 9 ( 𝑃 = 0 . 0 0 ) 1 . 3 8 ± 2 . 5 8 ( 𝑃 = 0 . 0 3 ) 1 . 3 3 ± 3 . 1 1 ( 𝑃 = 0 . 0 1 ) 1 . 2 3 ± 2 . 4 6 ( 𝑃 = 0 . 0 5 )
 Cylinder 4 . 0 3 ± 2 . 5 3 3 . 2 7 ± 2 . 2 1 ( 𝑃 = 0 . 0 0 ) 3 . 6 5 ± 2 . 6 2 ( 𝑃 = 0 . 0 1 ) 3 . 6 6 ± 2 . 4 1 ( 𝑃 = 0 . 0 0 ) 2 . 8 8 ± 2 . 0 0 ( 𝑃 = 0 . 0 0 )
CCT (μm) 4 5 1 ± 4 5 4 2 5 ± 5 8 ( 𝑃 = 0 . 0 0 ; 𝑛 = 2 1 ) 4 3 6 ± 4 5 ( 𝑃 = 0 . 0 0 ; 𝑛 = 3 1 ) 4 4 1 ± 5 8 ( 𝑃 = 0 . 8 1 ; 𝑛 = 2 6 ) 4 6 0 ± 4 7
( 𝑃 = 0 . 1 5 ; 𝑛 = 5 0 )

UDVA: uncorrected distance visual acuity; CDVA: corrected distance visual acuity; SE: spherical equivalent; CCT: central corneal thickness.