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Journal of Ophthalmology
Volume 2012, Article ID 564627, 7 pages
Clinical Study

Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls

1Neuro-Ophthalmology Division, Department of Ophthalmology, Eye Care Center (VGH), The University of British Columbia, 2550 Willow Street, Vancouver, BC, Canada V5Z 3N9
2Division of Neurology, Department of Medicine, University of British Columbia, S199 Koerner Pavillion, Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
3Departments of Clinical Neurosciences and Surgery and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 1N4

Received 22 January 2012; Accepted 14 March 2012

Academic Editor: Robert J. Zawadzki

Copyright © 2012 Alex P. Lange et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established. Design. Prospective, cross-sectional study. Participants. 28 MS patients and 35 HC. Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT. Results. A strong correlation (Pearson’s r=0.921, P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001). Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies.