Pilot Study of the Delivery of Microcollimated Pars Plana External Beam Radiation in Porcine Eyes: 270-Day Analysis
(a) Montage images of fundus photographs showing dose-dependent changes over the time course of the study. In the doses above 24 Gy, cotton wool spots, dot hemorrhage, and eventual atrophy were seen with depigmentation. (b) Montage images of fluorescein angiograms showing dose-dependent changes over the time course of the study. In the doses above 24 Gy, there was early retinal capillary changes with eventual pruning of vessels and late staining consistent with damage to the retinal pigment epithelium and retina vasculature. (c) ICG images demonstrating choroidal capillary obliteration at the 60 Gy and 90 Gy doses.