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Journal of Ophthalmology
Volume 2012 (2012), Article ID 728457, 6 pages
http://dx.doi.org/10.1155/2012/728457
Research Article

Interocular Asymmetry of Foveal Thickness in Parkinson Disease

1Department of Ophthalmology, SUNY Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
2SUNY Eye Institute, Brooklyn, NY 11023, USA
3College of Medicine, SUNY Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
4Department of Neurology, SUNY Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, USA

Received 3 March 2012; Revised 3 June 2012; Accepted 3 June 2012

Academic Editor: Brian Vohnsen

Copyright © 2012 Eric M. Shrier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls. Design. Prospective case-control series. Methods. In vivo assessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral domain optical coherence tomography (SD-OCT). Inner versus outer layer retinal segmentation and macular volumes were quantified using the manufacturer's software, while foveal thickness was measured using the raw data from each eye in a grid covering a 6 by 6 mm area centered on the foveola in 0.25 mm steps. Thickness data were entered into MATLAB software. Results. Macular volumes differed significantly at the largest (Zone 3) diameter centered on the foveola (ETDRS protocol). By segmenting inner from outer layers, we found that the IA in PD is mostly due to changes on the slope of the foveal pit at the radial distances of 0.5 and 0.75 mm (1.5 mm and 1 mm diameter). Conclusions. About half of the PD patients had IA of the slope of the foveal pit. IA is a potentially useful marker of PD and is expected to be comparable across different SD-OCT equipment. Data of larger groups may be developed in future multicenter studies.