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Journal of Ophthalmology
Volume 2012, Article ID 812034, 7 pages
Clinical Study

Pilot Study for OCT Guided Design and Fit of a Prosthetic Device for Treatment of Corneal Disease

1Boston Foundation for Sight, 464 Hillside Avenue, Suite 205, Needham, MA 02494, USA
2Center for Ophthalmic Optics and Lasers, Casey Eye Institute, Oregon University of Health & Science, Portland, OR, USA
3Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

Received 14 August 2012; Accepted 19 November 2012

Academic Editor: Norma Allemann

Copyright © 2012 Hong-Gam T. Le et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To assess optical coherence tomography (OCT) for guiding design and fit of a prosthetic device for corneal disease. Methods. A prototype time domain OCT scanner was used to image the anterior segment of patients fitted with large diameter (18.5–20 mm) prosthetic devices for corneal disease. OCT images were processed and analyzed to characterize corneal diameter, corneal sagittal height, scleral sagittal height, scleral toricity, and alignment of device. Within-subject variance of OCT-measured parameters was evaluated. OCT-measured parameters were compared with device parameters for each eye fitted. OCT image correspondence with ocular alignment and clinical fit was assessed. Results. Six eyes in 5 patients were studied. OCT measurement of corneal diameter (coefficient of variation, %), cornea sagittal height ( %), and scleral sagittal height ( %) is highly repeatable within each subject. OCT image-derived measurements reveal strong correlation between corneal sagittal height and device corneal height ( ) and modest correlation between scleral and on-eye device toricity ( ). Qualitative assessment of a fitted device on OCT montages reveals correspondence with slit lamp images and clinical assessment of fit. Conclusions. OCT imaging of the anterior segment is suitable for custom design and fit of large diameter (18.5–20 mm) prosthetic devices used in the treatment of corneal disease.