Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 4

Affected RPE-choroidal signaling pathways at different locations of cladogram in Figure 2. Sample identification follows http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29801. Updates on genes’ functions can be obtained from http://www.ncbi.nlm.nih.gov/gene/.

Dry 135; (Sample GSM738566); Lower part of the cladogram	Dry 145; (Sample GSM738575); Middle part of the cladogram	Dry 136; (Sample GSM738567); Upper part of the cladogram
(1) CXCL12: activates lymphocytes; (2) GDNF: promotes the survival and differentiation of dopaminergic neurons; (3) MAPK1: proliferation, differentiation, transcription regulation, and development; (4) PIK3CA: oncogenic; (5) SFRP1: soluble modulator of Wnt signaling; (6) SOD1 superoxide dismutase 1	(1) ABL1 protooncogene implicated in cell differentiation, division, adhesion, and stress response; (2) CAV1: cell cycle; (3) CCL20: inflammation; (4) CREB1: a transcription factor, cAMP pathway; (5) CRY2: insulin metabolism; (6) ERCC1: DNA repair; (7) ESR1: hormone binding, DNA binding, and activation of transcription; (8) IL8: inflammatory response; (9) INS: insulin; (10) MSN: cytoskeleton; (11) MT1A: cytoskeleton, and so forth; (12) PML: tumor suppressor; (13) SERPINE1: inhibitor of fibrinolysis; (14) TBP: assembly of transcription complex, and acts as a channel for regulatory signals; (15) TMSB4X: cytoskeleton, proliferation, migration, and differentiation	(1) CAV1: cell cycle; (2) CCL5: inflammation; (3) CXCL12: activates lymphocytes; (4) EGF: growth, proliferation, and differentiation; (5) PPARA peroxisome proliferator-activated receptor alpha