Journal of Ophthalmology / 2013 / Article / Tab 4

Research Article

Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 4

Affected RPE-choroidal signaling pathways at different locations of cladogram in Figure 2. Sample identification follows Updates on genes’ functions can be obtained from

Dry 135
(Sample GSM738566)
Lower part of the cladogram
Dry 145
(Sample GSM738575)
Middle part of the cladogram
Dry 136
(Sample GSM738567)
Upper part of the cladogram

(1) CXCL12: activates lymphocytes
(2) GDNF: promotes the survival and differentiation of dopaminergic neurons
(3) MAPK1: proliferation, differentiation, transcription regulation, and development
(4) PIK3CA: oncogenic
(5) SFRP1: soluble modulator of Wnt signaling
(6) SOD1 superoxide dismutase 1
(1) ABL1 protooncogene implicated in cell differentiation, division, adhesion, and stress response
(2) CAV1: cell cycle
(3) CCL20: inflammation
(4) CREB1: a transcription factor, cAMP pathway
(5) CRY2: insulin metabolism
(6) ERCC1: DNA repair
(7) ESR1: hormone binding, DNA binding, and activation of transcription
(8) IL8: inflammatory response
(9) INS: insulin
(10) MSN: cytoskeleton
(11) MT1A: cytoskeleton, and so forth
(12) PML: tumor suppressor
(13) SERPINE1: inhibitor of fibrinolysis
(14) TBP: assembly of transcription complex, and acts as a channel for regulatory signals
(15) TMSB4X: cytoskeleton, proliferation, migration, and differentiation
(1) CAV1: cell cycle
(2) CCL5: inflammation
(3) CXCL12: activates lymphocytes
(4) EGF: growth, proliferation, and differentiation
(5) PPARA peroxisome proliferator-activated receptor alpha

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