Journal of Ophthalmology / 2013 / Article / Tab 4

Research Article

Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 4

Affected RPE-choroidal signaling pathways at different locations of cladogram in Figure 2. Sample identification follows http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29801. Updates on genes’ functions can be obtained from http://www.ncbi.nlm.nih.gov/gene/.

Dry 135
(Sample GSM738566)
Lower part of the cladogram
Dry 145
(Sample GSM738575)
Middle part of the cladogram
Dry 136
(Sample GSM738567)
Upper part of the cladogram

(1) CXCL12: activates lymphocytes
(2) GDNF: promotes the survival and differentiation of dopaminergic neurons
(3) MAPK1: proliferation, differentiation, transcription regulation, and development
(4) PIK3CA: oncogenic
(5) SFRP1: soluble modulator of Wnt signaling
(6) SOD1 superoxide dismutase 1
(1) ABL1 protooncogene implicated in cell differentiation, division, adhesion, and stress response
(2) CAV1: cell cycle
(3) CCL20: inflammation
(4) CREB1: a transcription factor, cAMP pathway
(5) CRY2: insulin metabolism
(6) ERCC1: DNA repair
(7) ESR1: hormone binding, DNA binding, and activation of transcription
(8) IL8: inflammatory response
(9) INS: insulin
(10) MSN: cytoskeleton
(11) MT1A: cytoskeleton, and so forth
(12) PML: tumor suppressor
(13) SERPINE1: inhibitor of fibrinolysis
(14) TBP: assembly of transcription complex, and acts as a channel for regulatory signals
(15) TMSB4X: cytoskeleton, proliferation, migration, and differentiation
(1) CAV1: cell cycle
(2) CCL5: inflammation
(3) CXCL12: activates lymphocytes
(4) EGF: growth, proliferation, and differentiation
(5) PPARA peroxisome proliferator-activated receptor alpha

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