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Journal of Ophthalmology
Volume 2013, Article ID 925267, 8 pages
http://dx.doi.org/10.1155/2013/925267
Review Article

Vascular Adhesion Protein 1 in the Eye

1Department of Ophthalmology, 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150001, China
2Harbin Medical University-The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin 150001, China
3Department of Ophthalmology, 1st Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Received 17 January 2013; Revised 17 April 2013; Accepted 14 May 2013

Academic Editor: Nan Hu

Copyright © 2013 Wenting Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), a dual-function molecule with adhesive and enzymatic properties, is expressed on the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity and can be a prognostic biomarker. Recent evidence suggests that VAP-1 is an important therapeutic target for several inflammation-related ocular diseases, such as uveitis, age-related macular degeneration (AMD), and diabetic retinopathy (DR), by involving in the recruitment of leukocytes at sites of inflammation. Furthermore, VAP-1 plays an important role in the pathogenesis of conjunctival inflammatory diseases such as pyogenic granulomas and the progression of conjunctival lymphoma. VAP-1 may be an alternative therapeutic target in ocular diseases. The in vivo imaging of inflammation using VAP-1 as a target molecule is a novel approach with a potential for early detection and characterization of inflammatory diseases. This paper reviews the critical roles of VAP-1 in ophthalmological diseases which may provide a novel research direction or a potent therapeutic strategy.