Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

Table 4

Literature review of 13 choroidal new vessels associated with choroidal osteomas treated with intravitreal anti-VEGF injections∗.

Author	Age	Gender	Osteoma location & longest dimension	CNV location	Initial; vision	Final vision	Initial CFT; (microns)	Final CFT; (microns)	Type & number of injections	Follow-up (month)
Ahmadieh and Vafi [18]	19	F	Juxtafoveal 3DD OD	Juxtafoveal	6/60	6/7.5	544	240	One 1.25 mg bevacizumab	9 (regression of CNV)
Narayanan and Shah [19]	25	F	Peripapillary OS	Subfoveal	CF 1.5 m	6/35	NM	NM	Two 1.25 mg bevacizumab	4 (regression of CNV)
Shields et al. [20]	34	F	Subfoveal 7DD OD	Subfoveal	6/30	6/9	NM	NM	One 1.25 mg bevacizumab & three 0.5 mg ranibizumab	6 (fibrotic CNV with flat macula)
Song et al. [21]	24	M	Peripapillary 2.5DD	Juxtafoveal	CF 20 cm	6/60	NM	NM	Two 1.25 mg bevacizumab	10; prior to PDT
Song and Roh [22]	43	F	Subfoveal 4DD OS	Subfoveal	6/60	6/30	NM	NM	One 0.5 mg ranibizumab	6 (regression of CNV)
Rao and Gentile [23]	24	M	Subfoveal 2DD OS	Subfoveal	6/18	6/9	NM	NM	Three 1.25 mg bevacizumab	5
Ayachit et al. [24]	27	F	Peripapillary 3DD OD	Juxtafoveal	6/7.5	6/6	NM	NM	One bevacizumab (dose NM)	6 (regression of CNV)
Kubota-Taniai et al. [25]	12	F	Peripapillary 3DD OS	Extrafoveal	6/30	6/9	NM	NM	Two 1.25 mg bevacizumab	48 (regression of CNV)
Salehipour et al. [26]	19	F	NM	NM	NM	NM	NM	NM	Two 1.25 mg bevacizumab	7
Wu et al. [27]	46	F	Subfoveal OS	Subfoveal	6/30	6/12	NM	116 micron flattening	Two 1.25 mg bevacizumab	23
Wu et al. [27]	57	F	Peripapillary 10DD OD	Subfoveal	6/240	6/9	NM	NM	Three 0.5 mg ranibizumab	14 (fibrosis of CNV)
Carle et al. [28]	20	M	Macular OD	Occult	6/24	6/12	NM	NM	Six 1.25 mg bevacizumab	13
Erol et al. [29]	28	F	Peripapillary and macular 4DD OD	Subfoveal	6/120	6/24 after first injection and then 6/60 after second injection	NM	NM	Two 0.5 mg ranibizumab	2 (Tear of the retinal pigment epithelium after ranibizumab injection)

∗VEGF = vascular endothelial growth factor; CNV = choroidal neovascularization; CFT = central foveal thickness in microns; DD = disc diameter; NM = not mentioned; OD = right eye; OS = left eye; M = male; F = female; PDT = photodynamic therapy.