Clinical Characteristics of Alternaria Keratitis

Table 2

Previously reported cases of Alternaria keratitis.

Reference, report year	Age/sex	Risk factor	Antifungal medication	Surgery	Others
Azar et al., 1975 [2]	53/M	HSV keratitis	Topical natamycin	PKP
Ando and Takatori, 1987 [3]	53/F	PKP	Topical thimerosal, pimaricin, flucytosine
Chang et al., 1994 [4]	55/M	Trauma	Topical miconazole, fluconazole	PKP	Combined endophthalmitis
Arrese et al., 1996 [5]	46/M	Systemic steroids	Itraconazole	PKP
Daniel et al., 1997 [6]	45/M	Trauma	Topical ketoconazole
Koc et al., 1997 [7]	82/M	ECCE	Topical fluconazole
Ferrer et al., 2002 [8]	50/M	Trauma; Systemic steroids	Topical amphotericin B, fluconazole	PKP
Zahra et al., 2002 [9]	55/M	Trauma, DM	Topical amphotericin B
Ferrer et al., 2003 [10]	66/M	Trauma	Topical amphotericin B, fluconazole		Combined with endophthalmitis
Verma et al., 2005 [11]	29/F	LASIK	—	PKP	Diagnosis after PKP
Ozbek et al., 2006 [12]	69/M	Trauma	Topical natamycin, amphoterin B → topical and oral voriconazole
Barnes et al., 2007 [13]	59/M	KPro	Topical amphotericin B
Bunya et al., 2007 [14]	69/M		Topical amphotericin B, natamycin → topical and oral voriconazole
Kocaturk et al., 2007 [15]	46/F	LASIK	Topical amphotericin B + natamycin + oral itraconazole	PKP	PKP after resolution of infection
Tu, 2009 [16]	39/M	SCL	Topical voriconazole → oral voriconazole + topical natamycin → intrastromal injection of voriconazole + topical caspofungin
Tu, 2009 [16]	45/M	Trauma	Topical natamycin + oral itraconazole → topical fluconazole
Tu, 2009 [16]	70/M	COAG; DM	Topical fluconazole
Usui et al., 2009 [17]	55/M	Glaucoma	Topical fluconazole + miconazole → topical amphotericin B
Shen et al., 2010 [18]	62/F	Trauma	Topical natamycin + oral ketoconazole → intracameral voriconazole		Combined endophthalmitis
Ursea et al., 2010 [19]	72/F	RGP lens; Old PKP	Topical natamycin and amphotericin B	PKP
Yildiz et al., 2010 [20]	41/F	SCL	Topical natamycin → topical and oral voriconazole
Yildiz et al., 2010 [20]	26/F	SCL	Topical natamycin → topical voriconazole
Martone et al., 2011 [21]	68/M	Trauma	Topical + oral voriconazole
Neoh et al., 2011 [22]	67/M	Bullous keratopathy	Topical and intrastromal voriconazole + caspofungin	PKP
Konidaris et al., 2013 [23]	66/F	PKP	Topical and oral voriconazole + topical amphotericin B	PKP

M: male, F: female, HSV: herpes simplex virus, PKP: penetrating keratoplasty, ECCE: extracapsular cataract extraction, DM: diabetes mellitus, LASIK: laser-assisted in situ keratomileusis, Kpro: keratoprosthesis, SCL: soft contact lens, COAG: chronic open angle glaucoma, and RGP: rigid gas permeable lens.