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Journal of Ophthalmology
Volume 2014 (2014), Article ID 579190, 8 pages
Research Article

Corneal Biomechanical Changes after Crosslinking for Progressive Keratoconus with the Corneal Visualization Scheimpflug Technology

1Department of Ophthalmology, UKE-University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany
2Care-Vision Germany, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany

Received 20 June 2014; Accepted 3 September 2014; Published 22 September 2014

Academic Editor: Elias F. Jarade

Copyright © 2014 Johannes Steinberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate the effect of corneal crosslinking in progressive keratoconus by applying in vivo corneal visualization Scheimpflug technology. Design. Longitudinal retrospective study. Subjects and Controls. Seventeen eyes of patients treated with corneal crosslinking for progressive keratoconus. Methods. Corneal visualization Scheimpflug technology analyses (research software version 6.07r08) of subjects with progressive keratoconus before and 3 months after corneal crosslinking (CXL) were reviewed retrospectively. t-test (for normal distribution) and Wilcoxon matched-pairs test (if not normally distributed) were used to test for statistically significant differences between pre- and post-CXL analyses. Results. We demonstrated statistically significant differences for the intraocular pressure (median: +3 mmHg, ), the central corneal pachymetry (pachy; mean: −35 µm, ), the timespan between the air impulse release and the first applanation of the cornea (A1time; median: +0.12 ms, ), and the timespan between the air impulse release and the second applanation of the cornea (A2time; median: −37 ms, ). Conclusions. With the A1time and the A2time, we identified two parameters that demonstrated a statistically significant improvement of the biomechanical properties of the cornea after CXL. Despite the known initial decrease of the pachymetry after CXL, none of the analyzed parameters indicated a progression of the keratoconus.