Age-Related Macular Degeneration: Insights into Inflammatory Genes

Table 2

AMD genes involved in the inflammatory pathway.

Gene	Locus	Function
IL-1	2q14	Cytokine
IL-6	7p15.3	Cytokine
IL-8	4q12-q13	Chemokine
CCL3	17q11.2-q12	Chemokine
CCL4	17q11.2-q12	Chemokine
CCR3	3p21.3	Chemokine receptor
CFH	1q31	Complement factor H
C2	6p21.33	Complement component 2
CFB	6p21.33	Complement factor B
C3	19p13.3-p13.2	Complement component 3
C9	5p13.1	Complement component 9
CFI	4q25	Complement factor 1
ARMS2	10q26.16	Possible activation of proinflammatory molecules
NLRP3	1q44	Inflammasome