Genetics of Keratoconus: Where Do We Stand?

Table 2

Some of the genes reported in keratoconus using different genomic approaches.

Genes	Method	Population	Reference
MIR184	Linkage	Northern Irish	[30]
DOCK9	Linkage	Ecuadorian	[36]
VSX1	Candidate gene	European	[49]
ZEB1	Candidate gene	European	[62]
TGFB1	Candidate gene	Chinese	[64]
COL4A3/COL4A4	Candidate gene	European	[65]
FLG	Candidate gene	European	[70]
IL1A	Candidate gene	Korean, Chinese	[54, 71]
IL1B	Candidate gene	Korean, Japanese	[71, 72]
CAST	Linkage/candidate gene	Americans	[73]
SOD1	Candidate gene	Americans	[77]
HGF	GWAS	Australian, Americans	[102]
RAB3GAP1	GWAS	Americans, Australian	[103, 104]
LOX	Linkage/GWAS	Americans	[107]
MPDZ-NFIB, BANP-ZNF469	GWAS/candidate gene	European/Asian and Australian	[109, 111]
COL5A1	Linkage/GWAS	Americans	[112]
KRT72	Gene expression	European	[114]
TIMP1, TIMP3, BMP4,and CFL1	Gene expression	Korean	[74]