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Journal of Ophthalmology
Volume 2014, Article ID 689792, 4 pages
http://dx.doi.org/10.1155/2014/689792
Research Article

The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis

1Department of Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Youngdeungpo 4th 156, Youngdeungpo-gu, Seoul 150-034, Republic of Korea
2Department of Ophthalmology, Konyang University College of Medicine, Daejeon 302-718, Republic of Korea

Received 16 August 2014; Revised 18 October 2014; Accepted 29 October 2014; Published 13 November 2014

Academic Editor: Miguel Cordero-Coma

Copyright © 2014 Jung Jin Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis. Methods. In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable diplopia only, ptosis only, and both variable diplopia and ptosis. We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests. Results. Patients’ chief complaints were diplopia (), ptosis (), and their concurrence (). Abnormal anti-AChR-Ab was observed in 21 of 144 patients (14.1%). Between the three groups, mean age, number of seropositive patients, and mean anti-AChR-Ab level were not significantly different (, 0.073, and 0.062, resp.). Overall, 27.5% of patients had abnormal thyroid autoantibodies. Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected ocular myasthenia gravis and seropositivity in myasthenia gravis patients showed a high correlation with the presence of thyroid autoantibodies.